Chemical Tumor Ablation with Use of a Novel Multiple-tine Infusion System in a Canine Sarcoma Model

Hines-Peralta, Andrew; Liu, Zhengjun; Horkan, Clare; Solazzo, Stephanie; Goldberg, S. Nahum

doi:10.1097/01.rvi.0000196355.31419.1e

Cited by 18 publications

(12 citation statements)

References 24 publications

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“…Second, the multipronged technique allows infusion of ethanol in large aliquots with one injection. A study in animals has shown that the multipronged technique enabled greater fluid infusion (mean, 15-53 mL Ϯ 3) into a solid tumor than did standard needle injection (mean, 8 mL Ϯ 1) before reflux was observed at the puncture site (24). With the multiple-needle ethanol ablation technique, complete necrosis of target tumors could be achieved, but an average of six sessions and 10 days of hospitalization were required to complete a treatment course (18).…”

Section: Discussionmentioning

confidence: 98%

“…To improve the conventional ethanol ablation technique, a retractable multipronged injection needle was developed (24). The purpose of this study was to investigate whether ethanol ablation by using this needle delivery system (multipronged ethanol ablation) could eradicate HCC up to 5.0 cm in diameter with a single-session high-dose strategy, and we evaluated the treatment responses and complications.…”

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confidence: 99%

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Ethanol Ablation of Hepatocellular Carcinoma Up to 5.0 cm by Using a Multipronged Injection Needle with High-Dose Strategy

Kuang

Lu²,

Xie³

et al. 2009

Radiology

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Ethanol Ablation of Hepatocellular Carcinoma Up to 5.0 cm by Using a Multipronged Injection Needle with High-Dose Strategy

Kuang

Lu²,

Xie³

et al. 2009

Radiology

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“…To improve the efficacy of the conventional ethanol ablation technique in patients with tumors larger than 2 cm not treatable with other techniques, a retractable multipronged injection needle was developed [25] . This new ablation technique using the multipronged needle delivery system (multipronged ethanol ablation) has recently been proposed in a human study to treat larger HCCs in a single session.…”

Section: Peimentioning

confidence: 99%

Prognostic factors for hepatocellular carcinoma recurrence

Colecchia

Schiumerini

Cucchetti

et al. 2014

WJG

142

121

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The recurrence of hepatocellular carcinoma, the sixth most common neoplasm and the third leading cause of cancer-related mortality worldwide, represents an important clinical problem, since it may occur after both surgical and medical treatment. The recurrence rate involves 2 phases: an early phase and a late phase. The early phase usually occurs within 2 years after resection; it is mainly related to local invasion and intrahepatic metastases and, therefore, to the intrinsic biology of the tumor. On the other hand, the late phase occurs more than 2 years after surgery and is mainly related to de novo tumor formation as a consequence of the carcinogenic cirrhotic environment. Since recent studies have reported that early and late recurrences may have different risk factors, it is clinically important to recognize these factors in the individual patient as soon as possible. The aim of this review was, therefore, to identify predicting factors for the recurrence of hepatocellular carcinoma, by means of invasive and non-invasive methods, according to the different therapeutic strategies available. In particular the role of emerging techniques (e.g., transient elastography) and biological features of hepatocellular carcinoma in predicting recurrence have been discussed. In particular, invasive methods were differentiated from non-invasive ones for research purposes, taking into consideration the emerging role of the genetic signature of hepatocellular carcinoma in order to better allocate treatment strategies and surveillance follow-up in patients with this type of tumor.

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“…The latter consisted of three retractable tines that each had two evenly spaced through-holes (four fluid exits); the tines could be deployed up to 5 cm. 18 After administration of local anesthesia, the needle was inserted into the center of the tumor nodule under US guidance, and the tip of the needle was positioned at the inferior aspect of the tumor. For 21-gauge PEI, ethanol was injected until the entire tumor appeared hyperechoic upon using the pullback technique.…”

Section: Percutaneous Ethanol Injectionmentioning

confidence: 99%

Long-Term Outcome of Percutaneous Ablation in Very Early-Stage Hepatocellular Carcinoma

Kuang

Xie

Huang

et al. 2011

Journal of Gastrointestinal Surgery

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Chemical Tumor Ablation with Use of a Novel Multiple-tine Infusion System in a Canine Sarcoma Model

Cited by 18 publications

References 24 publications

Ethanol Ablation of Hepatocellular Carcinoma Up to 5.0 cm by Using a Multipronged Injection Needle with High-Dose Strategy

Ethanol Ablation of Hepatocellular Carcinoma Up to 5.0 cm by Using a Multipronged Injection Needle with High-Dose Strategy

Prognostic factors for hepatocellular carcinoma recurrence

Long-Term Outcome of Percutaneous Ablation in Very Early-Stage Hepatocellular Carcinoma

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