Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Ruminococcus gnavus

Pal, Debasish; Naskar, Mrinal; Bera, Anirban; Mukhopadhyay, Balaram

doi:10.1016/j.carres.2021.108384

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…The rhamnose backbone of glucorhamnan is made up of 1,2- and 1,3-linked rhamnose units, and the sidechain has a terminal glucose linked to a 1,6-glucose. Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide has been achieved (Haynie et al 2021 , Pal et al 2021 ). The synthesized pentasaccharide repeat of glucorhaman was sufficient to induce an immune response and release of inflammatory cytokines such as TNF-α and IL-6 from BMDCs through TLR4 receptor recognition (Haynie et al 2021 ).…”

Section: Molecular Mediators Underpinning the Effect Of R G...mentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extra-intestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterisation of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonisation of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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Section: Molecular Mediators Underpinning the Effect Of R G...mentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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“…Ruminococcaceae abundance was also significantly greater in high-market-weight chickens and this data combined with the CAG results linked this family to enhanced growth performance. Ruminococcaceae is one of the earliest described bacteria of the bovine rumen and are highly efficient carbohydrate decomposers and central to the degradation of resistant starch via fermentation to glucose and xylose (Pal et al, 2021). We also found that Ruminococcaceae UCG-004 was significantly correlated with 27/58 differential metabolites and 10 of these were fatty acid metabolites (listed in Figure 7 with the prefix PC).…”

Section: Discussionmentioning

confidence: 53%

Metabolic and inflammatory linkage of the chicken cecal microbiome to growth performance

Wang

Zhang

et al. 2023

Front. Microbiol.

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IntroductionChinese indigenous chicken breeds are widely used as food in China but their slow growth rate and long farming cycle has limited their industrial production.MethodsIn the current study we examined whether the market weights of native chicken breeds were related to specific cecal bacteria, serum metabolites and inflammatory cytokines. We examined cecal bacterial taxa using 16S rDNA analysis along with untargeted serum metabolites and serum inflammatory cytokines.ResultsWe found that the cecal microbiota could explain 10.1% of the individual differences in chicken weights and identified key cecal bacterial genera that influenced this phenotype. The presence of Sphaerochaeta spp. improved growth performance via bovinic acid metabolism. In contrast, Synergistes and norank_f_Desulfovibrionaceae had a negative effect on growth by inducing expression of the inflammatory cytokine IL-6.DiscussionWe were able to link specific bacterial genera with growth promotion in chickens and this study will allow further development of their use as probiotics in these animals.

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“…Ruminococcus can stabilize the intestinal barrier and reduce the risk of colorectal cancer. 42 In addition, many studies have shown that Oscillospira has also the capability to produce SCFAs such as butyrate. 43 Serum TC content was significantly and positively correlated with the abundance of Anaerostipes and Coprococcus but significantly and negatively correlated with the abundance of Phascolarctobacterium , Allobaculum , and Lactobacillus .…”

Section: Resultsmentioning

confidence: 99%