Abstract:Introduction of cationic modifications into an oligonucleotide can increase its nuclease resistance and duplex‐ or triplex‐forming abilities. In a recent study, we found that the nuclease resistance and RNA binding selectivity of an oligonucleotide containing a 5′‐(R)‐amino‐5′‐deoxy‐5′‐(R)‐hydroxymethylthymidine residue were greater than those of the unmodified oligonucleotide. In this article, we describe the synthesis of 5′‐amino‐5′‐deoxy‐5′‐hydroxymethylthymidine via dihydroxylation of the 5′‐alkene derivat… Show more
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