Chemical synthesis and sensing in inexpensive thread-based microdevices

Banerjee, Soumik; Roychowdhury, Abhijit; Taneja, Neetika; Janrao, Ravindra Ashok; Khandare, Jayant; Paul, Debjani

doi:10.1016/j.snb.2013.06.036

Cited by 39 publications

(33 citation statements)

References 16 publications

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“…Li et al conducted a semi-quantitative assay of NO 2 À on stitches of an indicatortreated cotton thread sewn into a polymer film support. They used a desk top scanner to convert the assay results into electronic images and measured the colour density of the stitches of thread and established calibration curves using serially diluted NO 2 À solutions (0, 125, 250, Treatments for increasing hydrophilicity Plasma oxidation 4 Plasma oxidation 30 Boiling 7 Mercerization 6 Washing with sodium carbonate 8 As received 36 Boiling in sodium carbonate (1.5 wt%) and hand soap solution 24 Treatment toward increasing hydrophobicity Mixing ratio controller 5 On/Off switch 18 Human body fluid (simulated/real) Urine 6,8 Whole blood 30,36 Blood plasma 36 Sweat 24,34 Blood plasma 36 …”

Section: Diagnostic and Synthetic Applicationsmentioning

confidence: 99%

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Exploration of microfluidic devices based on multi-filament threads and textiles: A review

2013

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In this paper, we review the recent progress in the development of low-cost microfluidic devices based on multifilament threads and textiles for semi-quantitative diagnostic and environmental assays. Hydrophilic multifilament threads are capable of transporting aqueous and non-aqueous fluids via capillary action and possess desirable properties for building fluid transport pathways in microfluidic devices. Thread can be sewn onto various support materials to form fluid transport channels without the need for the patterned hydrophobic barriers essential for paper-based microfluidic devices. Thread can also be used to manufacture fabrics which can be patterned to achieve suitable hydrophilic-hydrophobic contrast, creating hydrophilic channels which allow the control of fluids flow. Furthermore, well established textile patterning methods and combination of hydrophilic and hydrophobic threads can be applied to fabricate low-cost microfluidic devices that meet the low-cost and low-volume requirements. In this paper, we review the current limitations and shortcomings of multifilament thread and textile-based microfluidics, and the research efforts to date on the development of fluid flow control concepts and fabrication methods. We also present a summary of different methods for modelling the fluid capillary flow in microfluidic thread and textile-based systems. Finally, we summarized the published works of thread surface treatment methods and the potential of combining multifilament thread with other materials to construct devices with greater functionality. We believe these will be important research focuses of thread- and textile-based microfluidics in future.

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Section: Diagnostic and Synthetic Applicationsmentioning

confidence: 99%

“…36 Besides the many different instances of colorimetric detections on thread, Wei et al developed a method of electrophoretic separation and electrochemical detection of ion samples using thread. In their study, plasma treated and untreated polyester threads were affixed on a PMMA chip using protruding sleeper structures.…”

Section: -13mentioning

confidence: 99%

Exploration of microfluidic devices based on multi-filament threads and textiles: A review

2013

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“…Thread refers to thin strand of cotton, nylon, or other fibers and the wicking property of which facilitates the fluidic flow without using an external pumping system. There are a few reports demonstrating the capacity of threadbased microfluidics to be used in electrochemical detection Caetano et al, 2018;Carneiro et al, 2018;Song et al, 2017), electrochemiluminescence detection Liu et al, 2016), chemical sensing and synthesize (Banerjee et al, 2013;Cabot et al, 2018;Erenas et al, 2016;Li et al, 2017), immunochromatographic assays Liu et al, 2017;Meng et al, 2017;Seth et al, 2018;Zhou et al, 2012), capillary electrophoresis electrochemical (CE-EC) detection Wei et al, 2012), pH sensing (Lyu et al, 2018;Punjiya et al, 2017) and cell culture . Therefore, no hydrophobic barriers are required for the formation of microchannels, neither the mechanical pumps for the transportation of solutions.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in thread-based microfluidics for diagnostic applications

Weng

Kang

Guo

et al. 2019

Biosensors and Bioelectronics

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Keywords:Thread-based microfluidics Point-of-care Cotton Colorimetric Electrochemical A B S T R A C T Over the past decades, researchers have been seeking attractive substrate materials to keep microfluidics improving to outbalance the drawbacks and issues. Cellulose substrates, including thread, paper and hydrogels are alternatives due to their distinct structural and mechanical properties for a number of applications. Thread have gained considerable attention and become promising powerful tool due to its advantages over paper-based systems thus finds numerous applications in the development of diagnostic systems, smart bandages and tissue engineering. To the best of our knowledge, no comprehensive review articles on the topic of thread-based microfluidics have been published and it is of significance for many scientific communities working on Microfluidics, Biosensors and Lab-on-Chip. This review gives an overview of the advances of thread-based microfluidic diagnostic devices in a variety of applications. It begins with an overall introduction of the fabrication followed by an in-depth review on the detection techniques in such devices and various applications with respect to effort and performance to date. A few perspective directions of thread-based microfluidics in its development are also discussed. Thread-based microfluidics are still at an early development stage and further improvements in terms of fabrication, analytical strategies, and function to become low-cost, low-volume and easy-to-use pointof-care (POC) diagnostic devices that can be adapted or commercialized for real world applications.

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“…Various paper channel fabrication techniques, such as photolithography, 3 printing, 7-10 oxygen plasma and laser treatment 11,12 are extensively employed. [20][21][22][23][24][25][26][27][28] Taking advantage of their greater tensile strength and better flexibility, threads allow easy channel fabrication since it is unnecessary to pattern hydrophobic barriers, in particular for 3D structures. 13,14 Colorimetric, 3,15 electrochemical, 16 electrochemiluminescent, 17 chemiluminescent, 18 and mass spectrometric 19 techniques are employed for μPADs signal acquisition.…”

Section: Introductionmentioning

confidence: 99%

“…21,22,29 These advantages also allow μTADs to realize some interesting improvements, including better control of the mixing and splitting of fluids by knotting or twisting threads, the timing of reactions by on/off style switches, and the accurate localization of detection zones. 24,28,31 Moreover, the insufficient passive mixing of sample and reagent by capillary flow is also regarded as a factor leading to the limited reproducibility. 32 Pump-free low-cost platforms are state-of-art designs in terms of their minimal/no power consumption, easy fabrication, and better acceptance from both academics and industry.…”

Section: Introductionmentioning

confidence: 99%

A siphonage flow and thread-based low-cost platform enables quantitative and sensitive assays

Mao

et al. 2015

Lab Chip

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For pump-free, material abundant, portable, and easy-to-operate low-cost microfluidics, a siphonage flow microfluidic thread-based analytical device (S-μTAD) platform enabling quantitative and sensitive assays was designed. Renewable and continuous siphonage flow allowed replicate sampling and detection on one channel/device, obviating some possible inconsistencies among channels or devices. Y-shaped channels were fabricated with polyester cotton blend thread, due to its greater chemiluminescent sensitivity in comparison with that of cotton and polyester threads. S-μTAD sensors for glucose and uric acid were fabricated by using oxidase-immobilized cotton thread as the sample arm of the channels. The acceptable reproducibility and high sensitivity, demonstrated by the relative standard deviations of less than 5% in all cases and the detection limits of 4 × 10(-8) mol L(-1) for hydrogen peroxide, 1 × 10(-7) mol L(-1) for glucose, and 3 × 10(-6) mol L(-1) for uric acid, demonstrated the feasibility of the S-μTAD for quantitative assays. Good agreements between S-μTAD/sensor results and hospital results for blood glucose and uric acid assays indicated the capability of S-μTAD/sensors for the analysis of real samples. These findings proved the utility of siphonage for low-cost microfluidics and the suitability of our S-μTAD design for quantitative assays.

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Chemical synthesis and sensing in inexpensive thread-based microdevices

Cited by 39 publications

References 16 publications

Exploration of microfluidic devices based on multi-filament threads and textiles: A review

Exploration of microfluidic devices based on multi-filament threads and textiles: A review

Recent advances in thread-based microfluidics for diagnostic applications

A siphonage flow and thread-based low-cost platform enables quantitative and sensitive assays

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