Chemical sympathectomy increases neutrophil-to-lymphocyte ratio in tumor-bearing rats but does not influence cancer progression

Horváthová, Ľubica; Tillinger, Andrej; Sivakova, I; Mikova, Lucia; Mravec, Boris; Bucová, Mária

doi:10.1016/j.jneuroim.2014.11.014

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…This inflammatory marker was investigated in many diseases associated with non-cancer systemic inflammation [33,94] but is scarcely discussed in cancer [95]. Therefore, its clinical impact was still conflicted, and there is no evidence supporting the use of this marker in gynaecological cancer cases [33,[94][95][96]. Nevertheless, the aggressive nature of tumours with marked leukocytosis (an element of LPR) occurred in our baseline CBC results (Table 3).…”

Section: Discussionmentioning

confidence: 92%

“…Other markers revealed a non-significant role after adjustment in the multivariate analyses, one of which was LPR. This inflammatory marker was investigated in many diseases associated with non-cancer systemic inflammation [33,94] but is scarcely discussed in cancer [95]. Therefore, its clinical impact was still conflicted, and there is no evidence supporting the use of this marker in gynaecological cancer cases [33,[94][95][96].…”

Section: Discussionmentioning

confidence: 99%

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The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

Winarto

Habiburrahman

Anggraeni

et al. 2022

JCM

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Background: Given the role of inflammation in carcinogenesis, this study investigated the utility of pre-treatment inflammatory markers as associative indicators for advanced-stage disease, lymph node metastasis (LNM), and distant metastasis (DM) in vulvar cancer (VC). Methods: A cross-sectional study was conducted on 86 women with VC in a single centre in Jakarta, Indonesia. The laboratory data was based on C-reactive protein (CRP), procalcitonin, the erythrocyte sedimentation rate (ESR) and fourteen derived, recorded and calculated ratios: leukocyte-to-platelet (LPR), neutrophil-to-lymphocyte (NLR), derived neutrophil-to-lymphocyte (dNLR), neutrophil-to-monocyte (NMR), platelet-to-monocyte (PLR), lymphocyte-to-monocyte (LMR), basophil-to-monocyte (BLR), systemic immune-inflammation index (SII), body mass index, albumin, and NLR (BAN) score, haemoglobin-to-platelet (HPR), prognostic nutritional index (PNI), modified Glasgow Prognostic Score (mGPS), CRP-to-albumin, and CRP-to-procalcitonin. The optimal cut-off for each marker was determined using receiver operating characteristic (ROC) curve analysis, and their diagnostic indicator performances were assessed. The utility of these ratios as associative factors for three endpoints was further evaluated in multivariate regression models. Results: Investigated inflammatory markers exhibited specific performances for individual adverse outcomes, proving a fair to excellent ability in case finding and screening. After adjustment, the BAN score ≤334.89 (OR 9.20, p = 0.001) and ESR ≥104 (OR 4.18, p = 0.048) become two advanced-stage associative factors with AUC: 0.769. LNM was solely determined by higher NLR ≥2.83 (OR 4.15, p = 0.014) with AUC: 0.615. Meanwhile, BLR ≥0.035 (OR 5.67, p = 0.001) and ESR ≥84 (OR 6.01, p = 0.003) were contributing factors for DM, with AUC: 0.765. Conclusions: Inflammatory markers are crucial for identifying the deleterious outcomes of VC. Accordingly, yielded models require external validation.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

Winarto

Habiburrahman

Anggraeni

et al. 2022

JCM

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“…blood) shift in the neutrophil-to-lymphocyte ratio as well as increased tumor necrosis factor-alpha (TNF-a), suggesting increased extratumoral mobilization of innate immune cells. 27 By contrast, treatment with a betablocker, propranolol, was sufficient to slow tumor growth and metastasis in multiple models of melanoma, breast and pancreatic cancers. [28][29][30] Here, the authors analyzed tumor-infiltrating leukocytes (TILs) and found that blockade of beta adrenergic signaling was associated with a significant decrease in infiltration of myeloid cells (e.g.…”

Section: Sympathetic Nervous Systemmentioning

confidence: 99%

Neuroimmunology of cancer and associated symptomology

Scheff

Saloman

2021

Immunol Cell Biol

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Evolutionarily, the nervous system and immune cells have evolved to communicate with each other to control inflammation and host responses against injury. Recent findings in neuroimmune communication demonstrate that these mechanisms extend to cancer initiation and progression. Lymphoid structures and tumors, which are often associated with inflammatory infiltrate, are highly innervated by multiple nerve types (e.g. sympathetic, parasympathetic, sensory). Recent preclinical and clinical studies demonstrate that targeting the nervous system could be a therapeutic strategy to promote antitumor immunity while simultaneously reducing cancer-associated neurological symptoms, such as chronic pain, fatigue and cognitive impairment. Sympathetic nerve activity is associated with physiological or psychological stress, which can be induced by tumor development and cancer diagnosis. Targeting the stress response through suppression of sympathetic activity or activation of parasympathetic activity has been shown to drive activation of effector T cells and inhibition of myeloid-derived suppressor cells within the tumor. In addition, there is emerging evidence that sensory nerves may regulate tumor growth and metastasis by promoting or inhibiting immunosuppression in a tumor-type specific manner. Because neural effects are often tumor-type specific, further study is required to optimize clinical therapeutic strategies. This review examines the emerging evidence that neuroimmune communication can regulate antitumor immunity as well as contribute to development of cancer-related neurological symptoms.

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“…(2) Iron-defi ciency anaemia infl uences humoral, cell-mediated and nonspecifi c immunity, and is associated with an increased NLR. (3) Given that both dopamine imbalance and iron defi ciency are already associated with an increased NLR, I wonder what is new in this article.…”

Section: E T T E R T O T H E E D I T O Rmentioning

confidence: 99%

Increased neutrophil-to-lymphocyte ratio: is it really diagnostic of restless legs syndrome?

Afifi

2017

smedj

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Chemical sympathectomy increases neutrophil-to-lymphocyte ratio in tumor-bearing rats but does not influence cancer progression

Cited by 9 publications

References 42 publications

The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

Neuroimmunology of cancer and associated symptomology

Increased neutrophil-to-lymphocyte ratio: is it really diagnostic of restless legs syndrome?

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