Chemical Suppression of Adaptive Immunity

Gabrielsen, A E; Good, Robert A.

doi:10.1016/s0065-2776(08)60522-2

Cited by 194 publications

(49 citation statements)

References 476 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these agents that may selectively inhibit suppressor cells, Col may have the greatest potential for use as an adjuvant. With the exception of Col, these agents possess adjuvant activity over a narrow dose range and are more widely recognized as potent immunodepressants (58). In contrast, in the present studies, Col did not depress immune responsiveness when injected up to 24 h before assessment of the PFC response ( Figs.…”

Section: Inability Of Col Tocontrasting

confidence: 51%

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Parks¹,

Shaller²,

Weigle³

1979

The Journal of Experimental Medicine

View full text Add to dashboard Cite

The ability of colchicine (Col) to interfere with suppressor cells specific for the soluble protein antigen human gamma globulin (HGG) has been examined. This interference may be the mechanism of the adjuvanticity promoted by Col. When injected into A/J mice at the appropriate time and concentration, both Col and cyclophosphamide promoted an adjuvant increase in the plaque-forming cell response to 100 micrograms of immunogenic, aggregated HGG. Col abrogated both the induction of suppressor cells when injected with 3 h of tolerization with deaggregated (DHGG) and the expression of previously induced suppressor cells when injected with the antigenic challenge. Interference with the generation and expression of antigen-specific suppressor cells had no detectable effects on the immunologic unresponsive state to HGG. Col did not interfere with the induction of tolerance at a dose (1 mg/kg) that abolished the generation of suppressor cells. Furthermore, the absence of colchicine-sensitive-suppressor cells during the establishment of tolerance had no observable effect on the duration of unresponsivness in either helper T- or B-lymphocyte populations. Finally, Col was not able to terminate the unresponsive state established by DHGG even when responsive splenic B cells could be demonstrated in tolerant animals. These data indicate that suppressor cells are not required for the establishment and maintenance of the unresponsive state to this antigen.

show abstract

Section: Inability Of Col Tocontrasting

confidence: 51%

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Parks¹,

Shaller²,

Weigle³

1979

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…However, all of the agents have antiinflammatory as well as immunosuppressive actions (12)(13)(14). When given in low daily doses they may be exerting much of their effect through antiinflammatory mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic studies in NZB/W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone

Gelfand

Steinberg

1972

Arthritis & Rheumatism

View full text Add to dashboard Cite

Five-month-old female NZB/W mice were treated with daily injections of azathioprine, cyclophosphamide or methylprednisolone. Treatment was continued for 2 or 3 months at different dosages. Renal histology, proteinuria, antibodies to DNA and survival were studied. All drugs were found to modify the disease favorably. At low doses (1.5 mg/kg/day) azathioprine was most effective. Cyclophosphamide was superior at higher doses (4.5 mg/kg/day). Different two-drug combinations were also compared. The combination of cyclophosphamide plus methylprednisolone was most effective. Combined therapy increased survival without increasing toxicity.

show abstract

“…Although corticosteroids are known to suppress both cell-mediated and humoral immune responses in experimental animals (1)(2)(3)(4)(5)(6), their effects on immunity in man are only poorly understood (3,4). At the time when the effects in man were last studied systematically 20 yr ago, investigators employed relatively low doses of ACTH and cortisone acetate compared with presentday usage (3).…”

Section: Introductionmentioning

confidence: 99%

Effects of Corticosteroids on Immunity in Man I. DECREASED SERUM IgG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE

Butler¹,

Rossen²

1973

J. Clin. Invest.

312

View full text Add to dashboard Cite

A B S T R A C T To study the effects of methylprednisolone on immune mechanisms in the absence of other immunosuppressive agents or immunologically mediated diseases, we gave 17 normal adult male volunteers 96 mg of methylprednisolone daily for 3-5 days and compared results with 12 untreated controls who were studied simultaneously. 86% of treated volunteers had significant decreases in the concentrations of serum IgG. 2-4 wk after methylprednisolone, the treated volunteers had a mean decrease in IgG of 22% compared with a decrease of only 1 % in untreated controls. Likewise, significant decreases in IgA concentration occurred in 43% of treated volunteers, whereas significant decreases in IgM occurred in only 14%. The lowest immunoglobulin levels occurred during the 2nd wk after a 3 day course of methylprednisolone and during the 3rd wk after a 5 day course of drug. Slightly decreased plasma concentration of [HI] IgG was seen in six of seven volunteers who received a 5 day course but in only one of four who received a 3 day course of drug. However, an increase in the rate of plasma clearance of IgG occurred only during the treatment period itself. During the period when the serum concentration of IgG was falling, the specific activity of IgG in the serum was relatively higher in treated men than in controls indicating decreased entry of newly synthesized IgG into the circulation. These findings suggest that a short course of methylprednisolone treatment causes a pronounced and sustained decrease in serum IgG due to increased catabolism during drug administration and to decreased synthesis during and for a variable time after drug administration.

show abstract

Chemical Suppression of Adaptive Immunity

Cited by 194 publications

References 476 publications

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Therapeutic studies in NZB/W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone

Effects of Corticosteroids on Immunity in Man I. DECREASED SERUM IgG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE

Contact Info

Product

Resources

About