Chemical studies on Viburnum awabuki K. Koch.

Kuroyanagi, Masanori; Shiotsu, Michiko; Ebihara, Takeshi; Kawai, Hideaki; Ueno, Akihiko; Fukushima, Seigo

doi:10.1248/cpb.34.4012

Cited by 59 publications

(31 citation statements)

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“…The triterpene 3-oxo-6 β -hydroxy-lup-20(29)-en-28-oic acid was identified by analysis of its 1 H-. 13 C, DEPT, HMBC, and HSQC NMR spectra and comparison of 1 H- and 3 C-NMR spectra with literature data [ 44 ] as shown in Figure 4 . The ethyl p -coumaryl ether is a new propolis constituent and the triterpenic acid has been isolated from Hondurian propolis (Central America) [ 32 ] as shown in Figure 4 .…”

Section: Resultsmentioning

confidence: 97%

Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis

Savka

Dailey

Popova

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Propolis or bee glue has been used for centuries for various purposes and is especially important in human health due to many of its biological and pharmacological properties. In this work we showed quorum sensing inhibitory (QSI) activity of ten geographically distinct propolis samples from the United States using the acyl-homoserine lactone- (AHL-) dependent Chromobacterium violaceum strain CV026. Based on GC-MS chemical profiling the propolis samples can be classified into several groups that are as follows: (1) rich in cinnamic acid derivatives, (2) rich in flavonoids, and (3) rich in triterpenes. An in-depth analysis of the propolis from North Carolina led to the isolation and identification of a triterpenic acid that was recently isolated from Hondurian propolis (Central America) and ethyl ether of p-coumaric alcohol not previously identified in bee propolis. QSI activity was also observed in the second group US propolis samples which contained the flavonoid pinocembrin in addition to other flavonoid compounds. The discovery of compounds that are involved in QSI activity has the potential to facilitate studies that may lead to the development of antivirulence therapies that can be complementary and/or alternative treatments against antibiotic resistant bacterial pathogens and/or emerging pathogens that have yet to be identified.

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Section: Resultsmentioning

confidence: 97%

Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis

Savka

Dailey

Popova

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…They are 1b-hydroxyeudesm-4(15)-en-5a,6b,7a, 11bH-12,6-olide (2) (Marco, 1989), 1b-hydroxyeudesm-3-oxo-4b, 5a,6b,7a,11aH-12,6-olide (3) (Ahmed et al, 2003;Marco, 1989), a-bisabol (5) (Jequier, Nicollier, Tabacchi, & Garnero, 1980), 1S,2R,4S-trihydroxyl-p-methane (6) (Gomes & Antunes, 2001), (E)-3b,4b-epoxy-2-(2 0 ,4 0 -hexadiynylidene)-1,6-dioxaspiro[4,5] decane (9) (Birnecker, Wallnöfer, Hofer, & Greger, 1988), 2b-(2 0 ,4 0 -hexadiynoyl)-1,6-dioxaspiro[4,5]deca-3-ene (10) (Tan, Jia, Zhao, & Feng, 1992), chlorogenic acid butyl ester (11) (Rumbero-Sanchez & Vazquez, 1991), caffeic acid (12) and caffeic acid methyl ester (13) (Bolzani, Trevisan, & Young, 1991), 4-hydroxyl-3,5-dimethoxyl-6-O-b-D-glucosebenzene (14) (Cui et al, 1990), sabandinin (15) (Sarker, Gray, Waterman, & Armstrong, 1994), isoscopoletin (16) and scoparone (19) (Tsukamoto, Hisada, Nishibe, Roux, & Rourke, 1984), 6,8-dimethoxyl-7-O-b-D-glucosecoumarin (17) (Kuroyanagi et al, 1986), and 7-(3-methyl-2-butenyloxy)-6-methoxycoumarin (20) (Debenedetti, Nadinic, Coussio, De Kimpe, & Boeykens, 1998).…”

Section: Phytochemical Investigationmentioning

confidence: 99%

Unusual sesquiterpene lactones with a new carbon skeleton and new acetylenes from Ajania przewalskii

et al. 2010

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“…Separation of chemical components was monitored by TLC analyses. Appropriate fractions were combined: (i) the elution with gradients of hexane (100%) giving compounds 1,8,9,14,17; (ii) the elution with gradients of EtOAc/hexane (1: 10) giving compounds 2, 4,13,15,19; (iii) the elution with gradients of EtOAc/hexane (2: 10) giving compounds 3, 5, 7, 12, 18; (iv) the elution with gradients of EtOAc/hexane (3: 10) giving compounds 6,10,11,16. Purification of each compound was carried out by using flash CC and HPLC.…”

Section: Extraction and Isolationmentioning

confidence: 99%

The Chemical Constituents from the Heartwood of Eucalyptus Citriodora

Lee

Chang

2000

J Chinese Chemical Soc

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Nineteen compounds were isolated from the CHCl3 soluble portion of the heartwood of Eucalyptus citriodora. These compounds included trans‐calamenene (1), T‐muurolol (2), α‐cadinol (3), 2β‐hydroxy‐α‐cadinol (4), 4‐hydroxy‐3,5‐dimethoxybenzaldehyde (5), 4‐hydroxy‐3,5‐dimethoxybenzoic acid (6), linoleic acid (7), squalene (8), α‐tocopherol (9), erythrodiol (10), morolic acid (11), betulonic acid (12), cycloeucalenol (13), cycloeucalenol vernolitate (14), β‐sitosterol (15), β‐sitosteryl‐β‐D‐glucopyranoside (16), β‐sitostenone (17), yangambin (18), sesamin (19). Among them, 14 is a new compound. The structures of these compounds were elucidated on the basis of spectroscopic evidence.

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Chemical studies on Viburnum awabuki K. Koch.

Cited by 59 publications

References 0 publications

Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis

Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis

Unusual sesquiterpene lactones with a new carbon skeleton and new acetylenes from Ajania przewalskii

The Chemical Constituents from the Heartwood of Eucalyptus Citriodora

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