Chemical studies on antioxidant mechanism of garcinol: analysis of radical reaction products of garcinol and their antitumor activities

Sang, Shengmin; Pan, Min‐Hsiung; Cheng, Xiaofang; Bai, Naisheng; Stark, Ruth E.; Rosén, Robert; Lin‐Shiau, Shoei‐Yn; Lin, Ju‐Li; Ho, Chi‐Tang

doi:10.1016/s0040-4020(01)01015-8

Cited by 64 publications

(62 citation statements)

References 12 publications

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“…Literature revealed that garcinol exhibited antioxidant, antiinflammatory, anticancer and hepatoprotective activities [6][7][8][9] . Garcinol was also reported to exhibit radical scavenging activity and suppressed protein glycation in vitro [5] . Till date, the antidiabetic activity of garcinol has not been tested in vivo.…”

Section: Garcinol Is a Polyisoprenylated Benzophenone Derivative Isolmentioning

confidence: 99%

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Antidiabetic Effect of Garcinol on Streptozotocin-induced Diabetic Rats

Mali¹,

Dias²,

Havaldar³

et al. 2017

pharmaceutical-sciences

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Mali, et al.: Antidiabetic Effect of GarcinolThe objective of the present study was to investigate the antidiabetic effect of garcinol on streptozotocininduced diabetic rats. Acute toxicity of garcinol was studied according to the guidelines of Organization for Economic Co-operation and Development. Oral glucose tolerance test was used as a preliminary screening method. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (60 mg/kg). After induction of diabetes, rats were treated with garcinol (25, 50 and 100 mg/kg) and metformin (100 mg/ kg) for 28 days. Blood samples were collected for estimating biochemical parameters. Administration of garcinol caused significant reduction in elevated levels of blood glucose, glycosyated hemoglobin and lipids in diabetic rats. Histopathological study revealed regeneration of pancreatic β cells in the garcinol-treated groups. These results indicated that garcinol showed significant antidiabetic and lipid-lowering effects in streptozotocin-induced diabetes rats.

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Section: Garcinol Is a Polyisoprenylated Benzophenone Derivative Isolmentioning

confidence: 99%

“…Garcinol is structurally similar to a well-known antioxidant curcumin, which contained both phenolic hydroxyl groups and a β-diketone moiety [5] . Literature revealed that garcinol exhibited antioxidant, antiinflammatory, anticancer and hepatoprotective activities [6][7][8][9] .…”

Section: Garcinol Is a Polyisoprenylated Benzophenone Derivative Isolmentioning

confidence: 99%

Antidiabetic Effect of Garcinol on Streptozotocin-induced Diabetic Rats

Mali¹,

Dias²,

Havaldar³

et al. 2017

pharmaceutical-sciences

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“…[55] Garcinia indica (Thouars) Choisy: Garcinia indica extracts, especially from the rind, are rich in polyisoprenylated benzophenone derivatives such as garcinol [56] . Garcinol shows strong antioxidant activity which has been credited to both phenolic hydroxyl groups as well as a β-diketone moiety [57,58] . The effects of garcinol was associated with lowered concentrations of intracellular ROS, significant inhibition of 5-LOX and microsomal PGE 2 synthase (mPGES)-1 in cell-free assays [59] .…”

Section: Synonym -Woodfordia Floribundamentioning

confidence: 99%

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Sekhar¹,

Ruma²,

Kini³

et al. 2012

Phcog Commn

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“…Garcinol suppresses colonic aberrant crypt foci (ACF) formation, acts as a histone acetyltransferase (HATs) inhibitor, [7] and induces apoptosis through cytochrome c release and activation of caspase in human leukemia HL-60 cells. [8] More recently, they were shown to have anti-inflammatory and anticarcinogenic properties. [9,10] These compounds are reported to inhibit the NF-kB activation and COX-2 expression, and to decrease iNOS expression and NO release from LPS-stimulated macrophages by inhibition of the signal transducer and activator of transcription-1 (STAT-1).…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis and Absolute Configuration Assignment of MRSA Active Garcinol and Isogarcinol

Socolsky

Plietker

2014

Chemistry A European J

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A short total synthesis of (±)-garcinol and (±)-isogarcinol, two endo-type B PPAPs with reported activity against methiciline resistant Staphylococcus aureus (MRSA), is presented. The separation of framework-constructing from framework-decorating steps and the application of two highly regio- and stereoselective Pd-catalysed allylations, that is, the Pd-catalysed decarboxylative Tsuji-Trost allylation and the diastereoselective Pd-catalysed allyl-allyl cross-coupling, are key elements that allowed the total synthesis to be accomplished within 13 steps starting from acetylacetone. After separation of the enantiomers the absolute configurations of the four natural products (i.e., (-)-garcinol, (+)-guttiferone E (i.e., ent-garcinol), (-)-isogarcinol, and (+)-isoxanthochymol (i.e., ent-isogarcinol)) were assigned based on ECD spectroscopy.

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Chemical studies on antioxidant mechanism of garcinol: analysis of radical reaction products of garcinol and their antitumor activities

Cited by 64 publications

References 12 publications

Antidiabetic Effect of Garcinol on Streptozotocin-induced Diabetic Rats

Antidiabetic Effect of Garcinol on Streptozotocin-induced Diabetic Rats

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Total Synthesis and Absolute Configuration Assignment of MRSA Active Garcinol and Isogarcinol

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