Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems

Roth, Annika; Zhao, Piwen; Soukup, Sebastian T.; Guigas, Claudia; Stärke, Joachim; Kulling, Sabine E.; Diel, Patrick

doi:10.1016/j.toxlet.2022.12.002

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…In addition, Roth et al studied the purity and stability of tanshinone I ( 9 ), tanshinone IIA ( 1 ), cryptotanshinone ( 3 ), and dihydrotanshinone I ( 11 ) using liquid chromatography–diode array detection (LC-DAD) and liquid chromatography–mass spectrometry (LC-MS) analyses. Tanshinone I ( 9 ) and tanshinone IIA ( 1 ) were the most relevant bioactive tanshinones in Danshen, with no cytotoxic and genotoxic effects [ 33 ]. Currently, the extraction method for tanshinones from Danshen is inefficient, and Wei et al showed that combining transgenic technology with elicitor Ag+, yeast extract (YE), and methyl jasmonate (MJ) treatment can effectively increase the level of tanshinones [ 34 ].…”

Section: Main Components Of Danshenmentioning

confidence: 99%

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Tang,

Zhao

2024

Molecules

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As one of the traditional Chinese herbs, Danshen (Salvia miltiorrhiza Bunge) has been widely studied and widely used in the treatment of cardiovascular, cerebrovascular, and other immune diseases. Tanshinones and salvianolic acids isolated from Danshen are considered to be the main components of its biological activity and pharmacology that play important roles in increasing the index of immune organs, regulating the number and function of immune cells, and releasing immunoreactive substances. Especially tanshinone IIA, cryptotanshinone, salvianolic acid B, and rosmarinic acid show good biological activity in treating rheumatoid arthritis, some immune-mediated inflammatory diseases, psoriasis, and inflammatory bowel disease. In order to understand their pharmacological effects and provide references for future research and clinical treatment, the regulation of immune response by tanshinones and salvianolic acids is summarized in detail in this paper. In addition, the challenges in their pharmacological development and the opportunities to exploit their clinical potential have been documented.

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Section: Main Components Of Danshenmentioning

confidence: 99%

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Tang,

Zhao

2024

Molecules

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“…In addition to the above drugs, small molecule drugs such as Dihydromyricetin (DHM) ( Liang et al, 2014 ; Xu et al, 2023 ), β-Caryophyllene(BCP) ( Hu et al, 2022 ), Forsythoside A (FA) ( Zhang et al, 2024b ), 15, 16-Dihydrotanshinone I (DHT) ( Roth et al, 2023 ) ( Table 1 ) have been demonstrated to play a role in neurological impairment-related disorders by modulating the signalling factors associated with the Nrf2 pathway. However, their specific mechanisms still need to be verified more further.…”

Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

Ferroptosis inhibitors: past, present and future

Zhang,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of ferroptosis in disease. Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for the treatment of ferroptosis-mediated diseases. This article specifically describes the metabolic pathways of ferroptosis and summarizes the reported mechanisms of action of natural and synthetic small molecule inhibitors of ferroptosis and their efficacy in disease. The paper also describes ferroptosis treatments such as gene therapy, cell therapy, and nanotechnology, and summarises the challenges encountered in the clinical translation of ferroptosis inhibitors. Finally, the relationship between ferroptosis and other modes of cell death is discussed, hopefully paving the way for future drug design and discovery.

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Based on UHPLC–Q‐TOF–MS and bioinformatics strategies, the potential allergens and mechanisms of allergic reactions caused by Danshen injection were explored

Lei,

Zhiqi,

You

et al. 2024

Biomedical Chromatography

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The aim is to investigate the potential allergens and mechanisms underlying allergic‐like reactions induced by Danshen injection (DSI). Utilizing ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UHPLC–Q‐TOF–MS), metabolomics, and bioinformatics, we identified the key allergens, targets, and metabolic pathways involved in DSI‐induced allergic‐like reactions, validating binding efficiency through molecular docking and molecular dynamics. A total of 45 compounds were identified within DSI, with 24 compounds exhibiting strong binding activity to the MrgprX2 activation site. DSI was found to cause changes in 89 endogenous metabolites, including arachidonic acid, prostaglandins, and leukotrienes, primarily affecting pathways such as phenylalanine metabolism and arachidonic acid metabolism. The key allergens identified were Cryptotanshinone, Miltipolone, Neocryptotanshinone, Salvianolic acid B, and Isosalvianolic acid C, which primarily trigger allergic‐like reactions by regulating upstream signaling targets such as ALOX5, PTGS1, PPARD, and LTB4R. Validation confirmed the high binding affinity and stability between key allergens and targets. These findings indicate that the allergic components in DSI primarily induce allergic‐like reactions by modulating the aforementioned signaling targets, activating the AA metabolic pathway, promoting mast cell degranulation, and releasing downstream endogenous inflammatory mediators, subsequently eliciting allergic‐like reactions.

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Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems

Cited by 3 publications

References 27 publications

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Ferroptosis inhibitors: past, present and future

Based on UHPLC–Q‐TOF–MS and bioinformatics strategies, the potential allergens and mechanisms of allergic reactions caused by Danshen injection were explored

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