Chemical signal regulated injectable coacervate hydrogels

Abstract

Incorporation of reversible Michael addition controlled coacervate crosslinks in a polymer hydrogel led to injectable gels that are responsive to nucleophilic chemical signals, enabling accelerated degradation in culture media after injection.

Chemical reaction networks based on conjugate additions on β′-substituted Michael acceptors

“…61,62 Furthermore, cytotoxicity of even small-molecule Michael acceptors strongly depends on their structure, making biomedical applications possible depending on the choice of molecules. 63 Conjugate additions always involve the attack of a carbon-or heteroatom-centred nucleophile, i.e. Michael donor, on an electronpoor, unsaturated electrophile, called the Michael acceptor (Scheme 2A and B).…”

“…61,62 Furthermore, cytotoxicity of even small-molecule Michael acceptors strongly depends on their structure, making biomedical applications possible depending on the choice of molecules. 63…”

Nucleophile responsive charge-reversing polycations for pDNA transfection

“…We were inspired to investigate nucleophile responsive polycations after our recent work demonstrating controlled (de)cationization of polyvinylpyridine (PVP) copolymers by successive additions of an allyl acetate (ionization), and S/N-nucleophiles (deionization). 24,25 With an appropriate polyanion, the PVP copolymers (dis)assembled into coacervate core micelles, effectively achieving signal controlled polyanion encapsulation and release. 26 Importantly, we found that the decationiziation reaction is significantly faster for thiols compared to primary amines (Fig.…”

Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth

“…Based on the physical and chemical properties of hydrogels, they are widely used in the research of tissue engineering regeneration, especially for teeth with complex anatomical structures. Biocompatible hydrogels include injectable hydrogels [ 9 ], tissue-related hydrogels [ 10 ], nanocomposite hydrogels [ 11 ] and intelligent hydrogels [ 12 ]. Functional hydrogels are sensitive to physiological and pathological signals and have a wide range of biomedical applications [ 13 ].…”