Chemical reactivity of glycerol as a mass spectrometric matrix

Chan, Keith; Cook, Kelsey D.

doi:10.1021/ac00259a055

Cited by 13 publications

(1 citation statement)

References 35 publications

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“…Since a lot of previous studies in the early days of FAB have concerned the reduction process of various organic and inorganic compounds under particle bombardment conditions,1–4, 16–37 our first task was to summarize the available literature information. In this, we focused our attention mainly on aromatic heterocyclic compounds bearing structural similarity with the systems investigated in the present work.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the reduction of imidazophenazine dye derivatives under fast‐atom‐bombardment mass‐spectrometric conditions

et al. 2005

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Satellite [M + 2](+*) and [M + 3](+) peaks accompanying the common peak of the protonated molecule [M + H](+) that are known to indicate the occurrence of a reduction process were observed in the fast atom bombardment (FAB) mass spectra of imidazophenazine dye derivatives in glycerol matrix. The distribution of the abundances in the [M + nH](+) peak group varied noticeably for different derivatives. This indicated different levels of the reduction depending on the different structure variations of the studied molecules. In the search for correlations between the mass spectral pattern and the structural features of the dyes, ab initio HF/6-31++G** quantum chemical calculations were performed. They revealed that the abundances of the [M + 2](+*) and [M + 3](+) ions show growth proportional to the decrease of the energy of the lowest unoccupied molecular orbital, i.e. proportional to the increase of the electron affinity of the dye molecule. A method for rapid screening of reductive properties of sets of dye derivatives on the basis of the FAB mass spectral data is discussed.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the reduction of imidazophenazine dye derivatives under fast‐atom‐bombardment mass‐spectrometric conditions

et al. 2005

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Matrix compounds for fast atom bombardment mass spectrometry

Gower

1985

Biol. Mass Spectrom.

139

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The increasing number of applications for fast atom bombardment (FAB) mass spectrometry has seen a corresponding increase in the use of different matrix compounds. This review discusses briefly the use of matrix compounds in general and the use of cosolvents and/or additives with glycerol that assist in producing superior FAB mass spectra than when glycerol is used on its own. The main part of the review deals with alternative matrix compounds to glycerol including thioglycerol, polyethyleneglycols, triethanolamine, diamylphenol, crown ethers and various miscellaneous matrix compounds.

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Deuterium-labeled 3-nitrobenzyl alcohol as a matrix for fast atom bombardment mass spectrometry1

Reddy

Mykytyn

Schram

1989

Biol. Mass Spectrom.

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The utility of deuterium-labeled 3-nitrobenzyl alcohol (DNBA) as a fast atom bombardment (FAB) matrix for establishing the number of exchangeable hydrogens present in a molecule is illustrated by the analysis of five selected antitumor agents. A method for the simple preparation of this labeled matrix is described. The use of DNBA may be of value for samples which provide no FAB spectra when deuterium-labeled glycerol is used as a matrix.

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Chemical reactivity of glycerol as a mass spectrometric matrix

Cited by 13 publications

References 35 publications

Evaluation of the reduction of imidazophenazine dye derivatives under fast‐atom‐bombardment mass‐spectrometric conditions

Evaluation of the reduction of imidazophenazine dye derivatives under fast‐atom‐bombardment mass‐spectrometric conditions

Matrix compounds for fast atom bombardment mass spectrometry

Deuterium-labeled 3-nitrobenzyl alcohol as a matrix for fast atom bombardment mass spectrometry1

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