Chemical properties of a high molecular weight spleen extract with permeability activity

Davies, Huw Alban; Hartley, Rose E.; Schild, H. O.

doi:10.1007/bf01970289

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“…In the preceding paper [6] we have discussed some chemical properties of the high molecular weight permeability factor SPF 40/70. The long lasting inflammatory response of this type of reaction may thus be related to the slow liberation of high molecular weight releasing factors which, once liberated, could then rapidly release low molecular weight substances such as histamine and 5-HT.…”

Section: Functional Significance Of High Molecular Weight Permeabilitmentioning

confidence: 99%

The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: Investigation of their pharmacological properties

Davies¹,

Hartley²,

Schild³

1974

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A soluble extract from rat spleen, spleen permeability factor (SPF), predominantly protein in content, increases vascular permeability in rat skin by release of histamine and 5-HT from tissue stores. Increase in vascular permeability by SPF is markedly reduced by pretreatment with a combination ofmepyramine and methysergide or by local depletion of skin tissue amines by48/80. SPF releases histamine and 5-HT from rat peritoneal mast cells. This differs from histamine release by antigen, 48/80 and octylamine as it is blocked by 0.1 mM iodoacetic acid and is unaffected by calcium lack or by preheating the cells to 45~ for 5 minutes. There is no detectable kinin release by SPF which is devoid of general proteolytic or TAMe esterolytic activity at neutral pH. Nor does it seem to contain prostaglandins. The possible importance of SPF in the inflammatory response in delayed hypersensitivity reactions is discussed.

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Section: Functional Significance Of High Molecular Weight Permeabilitmentioning

confidence: 99%

The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: Investigation of their pharmacological properties

Davies¹,

Hartley²,

Schild³

1974

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Self Cite

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show abstract

Chemical properties of a high molecular weight spleen extract with permeability activity

Cited by 1 publication

References 0 publications

The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: Investigation of their pharmacological properties

The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: Investigation of their pharmacological properties

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