Chemical profiling of camptothecin and methoxy camptothecin in Nothapodytes nimmoniana Grah. (Mabb.) during seed development, seed germination and their effects on seed-borne pathogens

Sarika, G.; Amruta, Narayanappa; Kandikattu, Hemanth Kumar; Basavaraju, G. V.; Suma, H.K.; Manjunath, B. L.; Sravani, C.H.

doi:10.1016/j.sajb.2019.02.003

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…As shown in ▶ Table 2 and CPT (13) [40] and its representative natural analogues 9HCPT (6) [41] and 9MCPT ( 16) [10] are known compounds with substantial anticancer activity. Strictosidine (STR, 20) and strictosidine acid (STRA, 19) are key intermediates in the CPT biosynthetic pathway [42][43][44]. 9MMPE-Glc (1) is a novel E-ring-opened analogue of CPT, which may have good anticancer activity after being modified [34].…”

Section: Resultsmentioning

confidence: 99%

“…We thank Prof. Jun Luo (China Pharmaceutical University) for providing nine compounds (18)(19)(20)(21)(22)(23)(24)(25)(26) for this study.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Accepted Manuscript [17]. The limited content of CPT in C. acuminata (0.01%-0.14%, dry weight) and N. nimmoniana (0.003%-0.28%, dry weight) and the growing demand for CPT in the global pharmaceutical industry have caused a severe shortage of natural resources [3,18,19]. Accordingly, search for alternative CPT or CPT analogue-producing plants and improvement in the utilization of known resources would be of considerable importance.…”

Section: Introductionmentioning

confidence: 99%

“…Although the first total synthesis of CPT has been achieved in 1971 12 and a significant amount of work has been done on the optimization of the synthesis route over the past few decades 13 , 14 , 15 , 16 , industrial production of CPT-derived drugs still relies entirely on CPT isolated from plants such as C. acuminata and N. nimmoniana 17 . The limited content of CPT in C. acuminata (0.01 – 0.14%, dry weight) and N. nimmoniana (0.003 – 0.28%, dry weight) and the growing demand for CPT in the global pharmaceutical industry have caused a severe shortage of natural resources 3 , 18 , 19 . Accordingly, a search for alternative CPT or CPT analogue-producing plants and improvement in the utilization of known resources would be of considerable importance.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants

Chen

et al. 2023

Planta Med

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Camptothecin (CPT) and its derivatives have attracted worldwide attention due to their notable anticancer activity. However, the growing demand for CPT in the global pharmaceutical industry has caused a severe shortage of CPT-producing plant resources. In this study, phytochemical analysis of Nothapodytes tomentosa resulted in the isolation and identification of CPT (13) and 16 analogues (1-12, 14-17), including a new (1) and five known (9, 10, 12, 15 and 17) CPT analogues with an open E-ring. In view of the potential anticancer activity of CPT analogues with an open E-ring, the fragmentation pathways and mass spectra profiles of these six CPT analogues (1, 9, 10, 12, 15 and 17) were investigated, providing a reference for the rapid detection of these compounds in other plants. Furthermore, based on the fragmentation patterns of CPT (13) and known analogues (2-8, 11, 14, 16, 18-26), the distribution and content of these compounds in different tissues of N. tomentosa, N. nimmoniana, Camptotheca acuminata, and Ophiorrhiza japonica were further studied. Our findings not only provide an alternative plant resource for further expanding the development and utilization of CPT and its analogues, but also lay a foundation for improving the utilization of known CPT-producing plant resources.

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Section: Resultsmentioning

confidence: 99%

“…We thank Prof. Jun Luo (China Pharmaceutical University) for providing nine compounds (18)(19)(20)(21)(22)(23)(24)(25)(26) for this study.…”

Section: Acknowledgementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants

Chen

et al. 2023

Planta Med

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“…Pathogens propagated by seeds cause significant losses in seed yield and quality, resulting in low germinability and even damage to seedlings (Sarika et al, 2019). Many fungi are pathogenic to seeds, both in the field and during storage (Siegel & Babuscio, 2011).…”

Section: Main Fungal Pathogens Causing Seed Diseasesmentioning

confidence: 99%

Plant extract as a strategy for the management of seed pathogens: a critical review

Almeida

Silva

Souza

et al. 2021

RSD

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Seeds associated to fungal pathogens are efficient vehicles for disease dissemination in the field. Such pathogens affect the seed quality and longevity, causing a decrease or loss of germination, discoloration, necrosis, and decay, in addition to leading to the production of mycotoxins in some pathosystems. To control them several synthetic chemicals are used. Nevertheless, the use of synthetic chemicals poses a risk to human health and the environment. Therefore, there is a growing demand for the use of alternative methods for the treatment of seeds, such as plant extracts. This review evaluated the use and efficacy of plant extracts for the control of fungal pathogens associated to seeds. Some control methods are used in seed treatment, plant extracts stand out due to the secondary metabolic in their constitution, which inhibit pathogen growth. The literature review showed that 100% of the studies reported that plant extracts were efficient to control the different pathogens evaluated, 63% stated an increase in seed germination, 21% reported no change in germination, 5% mentioned negative interference, and 11% did not evaluate the use of plant extracts. The aqueous extracts were used as extractors in 72% of the studies. Plant extracts were reported as promising to replace synthetic fungicides in 33% of the studies; however, 67% did not compare their use. Nevertheless, efficient extraction methods are required, considering low persistence and volatilization of plant extracts in the field. Plant extracts are efficient to control fungal pathogens.

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Typification of two names in Nothapodytes (Icacinaceae)

Darshetkar,

Godbole,

Nadaf

et al. 2023

Kew Bull

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Chemical profiling of camptothecin and methoxy camptothecin in Nothapodytes nimmoniana Grah. (Mabb.) during seed development, seed germination and their effects on seed-borne pathogens

Cited by 14 publications

References 42 publications

Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants

Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants

Plant extract as a strategy for the management of seed pathogens: a critical review

Typification of two names in Nothapodytes (Icacinaceae)

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