Chemical profiling and in vitro biological effects of Cardiospermum halicacabum L. (Sapindaceae) aerial parts and seeds for applications in neurodegenerative disorders

Menichini, Francesco; Losi, Luigi; Bonesi, Marco; Pugliese, Alessandro; Loizzo, Monica Rosa; Tundis, Rosa

doi:10.3109/14756366.2013.840614

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…Cholinesterase inhibitors are currently used as a drug for the treatment of AD. The inhibitors increase brain acetylcholine (ACh) levels by preventing the breakdown of ACh and this case is very important to cognitive function (Menichini et al, 2014 ). Again, α-amylase and α-glucosidase release glucose from larger carbohydrates (especially starch) and are key enzymes in DM glucose level control (Kubinova et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

et al. 2017

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The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. The predominant phenolics were apigenin, luteolin, and quercetin in the tested extracts. Generally, the ethyl acetate and methanol extracts were noted as the most active in the antioxidant and enzyme inhibitory assays. Water extract with different concentrations indicated high level of DNA protection activity. Methanol and ethyl acetate extracts showed antibacterial effect against to Staphylococcus aureus and Staphylococcus epidermidis strains. The cytotoxic effects of O. natrix subsp. hispanica extracts on the survival of HeLa and PC3 cells were determined by MTT cell viability assay. Water and methanol extracts caused initiation of apoptosis for PC3 cell line. Furthermore, molecular docking was performed to better understand interactions between dominant phenolic compounds and selected enzymes. Our results clearly indicate that O. natrix subsp. hispanica could be considered a potential candidate for designing novel pharmaceuticals, cosmeceuticals and nutraceuticals.

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Section: Resultsmentioning

confidence: 99%

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

et al. 2017

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“…The extract of C. halicacabum was analyzed for its total phenol and flavonoid content as previously described. 9 …”

Section: Methodsmentioning

confidence: 99%

“…Several chemical constituents have been isolated from its, ie, β-arachidic acid, apigenin, apigenin-7- O -glucuronide, chrysoeriol-7- O -glucuronide, rutin, and luteolin-7- O -glucuronide. 7 – 9 Various fatty acids were also isolated from seed oil. 10 The plant-based herbal products like gel, cream, shampoo, spray, medical drops, and pills are commercially available and are helpful in dry itchy skin and scalp and in the treatment of chronic skin diseases, including psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90

Gaziano¹,

Campione²,

Iacovelli³

et al. 2018

DDDT

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IntroductionDermatophytosis is a superficial fungal infection limited to the stratum corneum of the epidermis, or to the hair and nails, and constitutes an important public health problem because of its high prevalence and associated morbidity. Dermatophyte fungi, especially 2 species, Trichophyton rubrum and Trichophyton mentagrophytes, are the predominant pathogens. Topical antifungal drugs, mainly azoles or allyamines, are currently used for the treatment of dermatophytoses, although in some cases, such as in nail and hair involvement, systemic treatment is required. However, therapeutic efficacy of current antifungal agents can be limited by their side effects, costs, and the emergence of drug resistance among fungi. Plant extracts represent a potential source of active antimicrobial agents, due to the presence of a variety of chemical bioactive compounds. In the present work, we evaluated in silico and in vitro the antifungal activity of an extract of the medicinal plant Cardiospermum halicacabum against T. rubrum suggesting a potential interaction with Hsp90 as playing an important role in both pathogenicity and drug susceptibility of T. rubrum.MethodsWe investigated in vitro the effect of different concentrations of C. halicacabum (from 500 to 31.25 µg) against a clinical isolate of T. rubrum. Furthermore, using a computational assessment, the interaction between different C. halicacabum active compounds and the fungal Hsp90 was also investigated.ResultsOur results indicate a clear-cut antifungal activity of the total plant extract at the highest concentrations (500 and 250 µg). Among all tested C. halicacabum compounds, the luteolin and rutin molecules have been identified in silico as the most important potential inhibitors of Hsp90. Based on these data, luteolin and rutin were also individually assessed for their antifungal activity. Results demonstrate that both substances display an antifungal effect, even if lower than that of the total plant extract.ConclusionOur data indicate a strong fungistatic effect of C. halicacabum against T. rubrum, suggesting its potential therapeutic efficacy in the treatment of dermatophytoses. Additionally, C. halicacabum compounds, and particularly luteolin and rutin, are all possible Hsp90 interactors, explaining their fungistatic activity.

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“…The aqueous extracts also showed a myocardial depressive effect similar to that obtained with cholinergic agents, which was partially blocked by atropine. [39][40][41][42][43] Some research has shown antimalarial activity of the extracts of this plant as well as anti-inflammatory and analgesic, antiparasitic, anti-diarrheal, anti-diarroil, antihysterility, anti-sterility, nephroprotective; hepato-protective and anticancer activity. [44][45][46][47][48][49][50][51][52]…”

Section: Pharmacological Activitymentioning

confidence: 99%

Cardiospermum halicacabum Linn.: Food and Drug

Ferrara

2018

Int J Med Rev

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Medicinal plants are natural sources of bioactive phytochemical constituents which, for the physiological actions produced on the human organism, can be used against many diseases. For this reason, it is necessary for medicinal plants to be assessed for their phytochemistry in order to ascertain the potential of these indigenous sources of medicinal products. Today, people around the world are interested in using herbal medicines rather than synthetic drugs because of their minor side effects and low cost; however, there is little scientific evidence for the healing properties of these natural drugs. Scientific validation of their properties is required for their safe use. Cardiospermum halicacabum L., from the family Sapindaceae, is a widespread perennial plant, different parts of which have been used by indigenous populations in various parts of the world both as food and in the treatment of many pathologies. Knowledge of the plant's chemical components and their standardization and in vitro and in vivo experimentation to evaluate its pharmacological activity are means by which the quality of the drug and its possible toxicity can be controlled and adulterations with other similar species can be revealed in order to guarantee the safety and well-being of the consumer. The complex chemical composition and multiplicity of applications of C. halicacabum L. have attracted the attention of researchers who, applying modern methodologies, have ascertained the safety and validity of its use in the treatment of many pathologies.

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Chemical profiling and in vitro biological effects of Cardiospermum halicacabum L. (Sapindaceae) aerial parts and seeds for applications in neurodegenerative disorders

Cited by 17 publications

References 28 publications

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

Antifungal activity of <em>Cardiospermum halicacabum</em> L. (Sapindaceae) against <em>Trichophyton rubrum</em> occurs through molecular interaction with fungal Hsp90

Cardiospermum halicacabum Linn.: Food and Drug

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