Chemical profiling and antidiabetic potency of Paeonia delavayi: Comparison between different parts and constituents

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

“…Representative DPP-IV inhibitory flavonoids ( 1–72 ) and other aromatic compounds ( 73–100 ) are summarized in Table 1. 42–71 …”

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa

“…Paeonia suffruticosa (Paeoniaceae) is a medicinal plant indigenous to China with a long history of use in Traditional Chinese Medicine (TCM) and has become an important ornamental plant worldwide [5]. Traditionally, the root of P. suffruticosa has been utilised as a crude medicine for the treatment of extravagant blood, elimination of stagnant blood, and cardiovascular complications [6]. The biological activities of the plant are mainly attributed to monoterpene glycosides, such as paeoniflorin, benzoylpaeoniflorin, albiflorin, and paeoniflorigenone, and the plant is also rich in galloylglucoses, gallic acid derivatives, flavonoids, triterpenoids, and acetophenones [7].…”

“…The purpose of this study was to examine the antidiabetic components of the title plant. This article presents the separation, characterization, and enzyme inhibitory effect of phenolic compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) from the root bark of P. suffruticosa (Fig. 1).…”

“…1 H-NMR (CDCl 3 , 400 MHz) δ 8.12 (2H, d, J = 8.4 Hz, H-2, 6), 7.60 (1H, d, J = 7 6. Hz, H-4), 7.47 (2H, d, J = 8 4.…”

Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata

“…Our previous investigation on Chelonopsis plants yielded a series of diterpenoids with α-glucosidase inhibitory activity, i.e., ten ent-kauranes from C. praecox [10], and 13 ent-labdanes and 11 ent-kauranes from C. odontochila [11]. As a continuous search for antidiabetic candidates from natural sources [12][13][14][15][16], ten 3,5-dimethylcoumarins (1-6 and 8-11) involving six new ones and one known 3-methylcoumarin (7) were first isolated from three Chelonopsis plants (Fig. 1).…”