Chemical profile, liver protective effects and analgesic properties of a Solanum paniculatum leaf extract

Souza, Gabriela Rodrigues de; De-Oliveira, A.C.A.X.; Soares, Vitor; Chagas, Lucas F.; Barbi, Nancy S.; Paumgartten, Francisco José Roma; Silva, Antônio Jorge R. da

doi:10.1016/j.biopha.2018.11.036

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…Also, citrusin-B showed moderate inhibition activity against tobacco mosaic virus replication ( Tan et al., 2012 ). Further, citrusin-B was identified in different plant extracts and reported for their liver-protective property ( De Souza et al., 2019 ), anti-oxidant, and alpha-glucosidase inhibition properties ( Saleem et al., 2019 ) along with other natural compounds. In this docking study, citrusin-B showed more activity towards inhibiting HPA than alpha-glucosidase.…”

Section: Resultsmentioning

confidence: 99%

Investigation of effective natural inhibitors for starch hydrolysing enzymes from Simaroubaceae plants by molecular docking analysis and comparison with in-vitro studies

Mugaranja

Kulal

2022

Heliyon

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Section: Resultsmentioning

confidence: 99%

Investigation of effective natural inhibitors for starch hydrolysing enzymes from Simaroubaceae plants by molecular docking analysis and comparison with in-vitro studies

Mugaranja

Kulal

2022

Heliyon

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“…The results showed an absence of hepatoprotective effects and moderate steatosis in animals treated with both the extract and CCl 4 , as observed by histopathological assays. Extending the studies on this plant, Souza et al [119] . evaluated the effect of a leaf infusion (600 and 1200 mg/kg, p.o .)…”

Section: Resultsmentioning

confidence: 99%

“…Male C57BL/6 mice Acetaminophen (600 mg/kg, i. p.) [119] Root crude extract and alkaloid fraction (100 and 200 mg/kg, i. p.)…”

Section: Male Wistar Ratsmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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“…In a recent study, de Souza et al . [ 33 ] analyzed the analgesic potency of the traditional medicinal plant Solanum paniculatum , which is native to Brazil. The writhing test showed that treatment with the aqueous extract of the plant leaf (partitioned with ethyl acetate) at a dose of 300 mg/kg-body weight (bw) produced an approximately 50% reduction in the writhing nociceptive response.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics

Rengasamy

Mahomoodally

Joaheer

et al. 2021

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: Pain is a distressing but fundamental manifestation that prepares the body for potentially detrimental stimuli while ensuring its protection. Plant and animal products have traditionally been used to relieve pain for centuries. However, no attempt has been made to compile a single report of plant and animal products possessing analgesic properties. This review enadeavours to recover data from published articles to establish a collective literature review on folk remedies from plant and animal sources used as analgesics and in the treatment of pain-related conditions, identifying gaps in existing knowledge and future works. Relevant information was systematically retrieved using the PRISMA method. In this review, in total, 209 plants were found to be either used raw or prepared by decoctions or maceration. Administration was either oral or topical, and they were predominantly used in Asian countries. In vivo studies of plants with analgesic properties, which were tested using different methods including acetic-induced writhing test, hotplate test, tail-flick test, and formalin-induced pain test, were compiled. Animal products with analgesic properties were obtained mainly from compounds present in venom; their bioactive compounds were also identified. In the literature search, certain gaps were noted, which could be reviewed in future studies. For instance, there was a disparity of information regarding the traditional uses of medicinal plants. In this review, an attempt was made to critically assess and describe the pharmacological properties and bioactive composition of indigenous plants, some animal species, and animal venom by scrutinizing databases and looking for published articles. Therefore, it can be concluded that the compounds obtained from these sources can serve as important ingredients in therapeutic agents to alleviate pain once their limitations are assessed and improved upon. In the literature search, certain gaps were noted, which could be reviewed in future studies.

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Chemical profile, liver protective effects and analgesic properties of a Solanum paniculatum leaf extract

Cited by 16 publications

References 41 publications

Investigation of effective natural inhibitors for starch hydrolysing enzymes from Simaroubaceae plants by molecular docking analysis and comparison with in-vitro studies

Investigation of effective natural inhibitors for starch hydrolysing enzymes from Simaroubaceae plants by molecular docking analysis and comparison with in-vitro studies

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics

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