Chemical Profile, In Vitro Enzyme Inhibitory, and Antioxidant Properties of Stereum Species (Agaricomycetes) from Turkey

Çayan, Fatih; Tel‐Çayan, Gülsen; Deveci, Ebru; Duru, Mehmet Emin

doi:10.1615/intjmedmushrooms.2019032893

Cited by 26 publications

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“…[20,21] It can be found throughout the year. Mycelia of Stereum species has been reported to contain various bioactive secondary metabolites, such as epidioxysterol with activity against Mycobacterium tuberculosis, [22] phenolic compounds with antioxidant and enzyme inhibitory activities, [23,24] tricyclic sesquiterpenes with antibacterial and antioxidant activities, [20,21] and fatty acids. [23] Free radicals, continuously derived from either essential metabolic processes or external sources, are associated with the appearance of oxidative stress, which represent a major pathomechanism of numerous diseases, including heart disease, cancer etc.…”

Section: Introductionmentioning

confidence: 99%

“…Mycelia of Stereum species has been reported to contain various bioactive secondary metabolites, such as epidioxysterol with activity against Mycobacterium tuberculosis, [22] phenolic compounds with antioxidant and enzyme inhibitory activities, [23,24] tricyclic sesquiterpenes with antibacterial and antioxidant activities, [20,21] and fatty acids. [23] Free radicals, continuously derived from either essential metabolic processes or external sources, are associated with the appearance of oxidative stress, which represent a major pathomechanism of numerous diseases, including heart disease, cancer etc. [25,26] These radicals, such as superoxide, singlet oxygen, and hydroxyl radicals may be generated as a result of oxygen metabolism during the course of normal cellular activity [26] and may even be helpful in certain settings such as inside a phagocytic vesicle where free radicals may assist in the destruction of invading microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…It can be found throughout the year. Mycelia of Stereum species has been reported to contain various bioactive secondary metabolites, such as epidioxysterol with activity against Mycobacterium tuberculosis , [22] phenolic compounds with antioxidant and enzyme inhibitory activities, [23,24] tricyclic sesquiterpenes with antibacterial and antioxidant activities, [20,21] and fatty acids [23] …”

Section: Introductionmentioning

confidence: 99%

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Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Rašeta

Popović

Knežević

et al. 2020

Chemistry & Biodiversity

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Medicinal mushrooms have tremendous potential in production of bioactive compounds with diverse bioactivities while the biochemical potential of some specific mushroom strains (autochthonous for the region) in production of specific bioactive agents may be of the main importance in a continuous search for novel strains with supreme activities all over the world. In this study, the ethanolic (EtOH) and water (H 2 O) extracts of wild-growing polypore mushroom species were investigated: Trametes versicolor (L.) Lloyd and Stereum subtomentosum Pouzar. This study was designed to determine total phenol (TP), flavonoid (TF) and protein content (TPR) as well as LC/MS/MS phenolic profile related to in vitro antioxidant, antiproliferative (MTT assay) (AP) and DNA fragmentation properties. The H 2 O extracts expressed better antioxidant scavenging potential than EtOH showing the highest activity for the T. versicolor (IC 50 = 5.6 μg/mL, IC 50 = 0.6 μg/mL for DPPH * and OH * , respectively) while O 2 *À activity achieved the best activity for S. subtomentosum (IC 50 = 4.1 μg/mL). In contrary, the highest AP activity was obtained for the EtOH extracts of S. subtomentosum (IC 50 = 141.1 μg/mL). The EtOH extracts of both species showed the highest TP, TF and TPR content. Obtained results of DNA degradation indicate genotoxicity potential of the extracts at high concentration. The LC/MS/MS detection showed that the majority of analyzed extracts contained phenolic acids, p-hydroxybenzoic and protocatechuic acid. The obtained results suggest that analyzed medicinal mushroom species, T. versicolor and S. subtomentosum, could be of potential interest as new sources of strong natural antioxidants as well as antiproliferative agents in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Rašeta

Popović

Knežević

et al. 2020

Chemistry & Biodiversity

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“…Antioxidant Activity β-carotene-linoleic acid, metal chelating, cupric reducing antioxidant capacity (CUPRAC), 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH • ), and (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt cation radical (ABTS •+ ) scavencing assays were performed for measurement of antioxidant activities of the extracts (17). The graph of the inhibition percentage (%) versus the concentration (μg/mL) was used to calculate the IC 50 values of the extracts.…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 99%

“…Results were given as a microgram of gallic equivalents (GAEs) using the following equation that was obtained from standard gallic acid graph: Absorbance=0.0104[gallic acid (µg)] -0.0263 (r 2 , 0.9974) Total flavonoid contents of extracts were measured by using the aluminum nitrate method (16). Results were given as microgram quercetin equivalents (QEs) using the following equation that was obtained from standard quercetin acid graph: Absorbance=0.0158[quercetin (µg)] -0.0306 (r 2 , 0.9993) Antioxidant Activity β-carotene-linoleic acid, metal chelating, cupric reducing antioxidant capacity (CUPRAC), 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH • ), and (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt cation radical (ABTS •+ ) scavencing assays were performed for measurement of antioxidant activities of the extracts (17). The graph of the inhibition percentage (%) versus the concentration (μg/mL) was used to calculate the IC 50 values of the extracts.…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Deveci¹,

Cayan²,

Karakurt³

et al. 2020

Eur J Biol

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The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents.Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay.Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC 50 : 32.72±0.15 µg/mL), CUPRAC (A 0.50 : 282.69±0.25 µg/mL), DPPH • (IC 50 : 71.69±0.85 µg/mL), and ABTS •+ (IC 50 : 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC 50 : 57.38 µg/mL) and C. monogyna (IC 50 : 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion:Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.

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Mushroom Species Stereum hirsutum as Natural Source of Phenolics and Fatty Acids as Antioxidants and Acetylcholinesterase Inhibitors

Mišković

Rašeta

Čapelja

et al. 2021

Chemistry & Biodiversity

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Many lignicolous mushroom species are used as a food supplement and may represent an alternative treatment of Alzheimer's disease (AD). This study aimed to evaluate acetylcholinesterase inhibition (AChEI) of Stereum hirsutum together with antioxidant activity (AO) and cytotoxic activity against HepG2 cells. Different extracts (water, ethanol, methanol, polysaccharide) were analyzed, with respect to their mineral composition and chemical content. Ethanol extract was the most potent in AChEI (98.44 %) and demonstrated cytotoxic activity (91.96 % at 900.00 μg/mL), while the highest AO was demonstrated for polar extracts (methanol and water) as well. These activities may be attributed to determined phenolics (hydroxybenzoic and quinic acid) and fatty acids (FA), while biflavonoid amentoflavone may be responsible for cytotoxic activity. The most prevalent FA was linoleic (40.00 %) and the domination of unsaturated FA (UFA) (71.91 %) over saturated (26.96 %) was observed. This is the first report of AChEI of S. hirsutum extracts and first detection of amentoflavone. Due to high amount of UFA and well-expressed AChEI, this species can be considered as a potent food supplement in the palliative therapy of AD.

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Chemical Profile, In Vitro Enzyme Inhibitory, and Antioxidant Properties of Stereum Species (Agaricomycetes) from Turkey

Cited by 26 publications

References 0 publications

Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Mushroom Species Stereum hirsutum as Natural Source of Phenolics and Fatty Acids as Antioxidants and Acetylcholinesterase Inhibitors

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