Chemical profile and biological activity of Crinum americanum L. (Amaryllidaceae)

Gomes, João Victor Dutra; Tosta, Cristina Luz; Neto, Álvaro da Cunha; Fagg, Christopher William; Silva, Cristian Aldemar Gasca; Gomes-Copeland, Kicia Karinne Pereira; Magalhães, Pérola Oliveira; Fonseca-Bazzo, Yris Maria; Jamal, Cláudia Masrouah; Silveira, Dâmaris

doi:10.1016/j.sajb.2021.09.034

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…Epibuphanamine has been reported for its antimicrobial effects 31 . Epipowelline has been reported to inhibit acetylcholinesterase or AChE in vitro studies 32 . Narcissidine has a role as an alkaloid with a defensive function against insect predators 40 …”

Section: Resultsmentioning

confidence: 99%

“…31 Epipowelline has been reported to inhibit acetylcholinesterase or AChE in vitro studies. 32 Narcissidine has a role as an alkaloid with a defensive function against insect predators. 40 Genistein is a phytoestrogen, precursor in the synthesis of antimicrobial phytoalexins and phytoanticipins in bean seeds, and has different pharmacological effects in animal cells, like tyrosine kinase inhibition, role in chemoprevention of breast and prostate cancers, cardiovascular disease (CVD), and post-menopausal ailments.…”

Section: Resultsmentioning

confidence: 99%

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Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

Das

Ghosh

2022

Chirality

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Chiral compounds find importance as drugs and therapeutic targets. Enantiomers of chiral drugs have been found to show different biological properties like pharmacokinetics, toxicology, pharmacology, metabolism, and so forth. In this study, we have identified the chiral compounds present in the medicinal plant Adhatoda vasica Nees (Justicia adhatoda Linn). Phytochemical investigation on the leaves of Justicia adhatoda resulted in the identification of 27 chiral compounds. We report diverse compounds identified in the crude methanolic extract of Justicia adhatoda leaves by GC-MS analysis exhibiting diverse biological activities. Quantitative analysis of anticancer compound dihydroxycolchicine from the methanolic extract of J. adhatoda leaves was done by external standard method, and the amount of anticancer compound dihydroxycolchicine was found to be 87.823 mg/l indicative of moderate production in the leaves. Therefore, the extract of leaves of Justicia adhatoda can be used as a potential source of chiral bioactive molecules of pharmacological importance for drug synthesis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

Das

Ghosh

2022

Chirality

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“…Gas chromatography (GC) is less used due to the low volatility and relatively high polarity of alkaloids. However, the application of GC-MS for alkaloid analysis is possible by direct analysis, 27,54,55 and with prior derivatization. 52,56…”

Section: Traditional Workflow In the Study Of Alkaloidsmentioning

confidence: 99%

Sustainable approaches for the study of alkaloids from plants using supercritical fluid-based processes

et al. 2022

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Anti-diabetic, antiglycant, antioxidant, and anticancer activities of Crinum americanum L. leaves lipid fraction

de Araújo,

de Pinho,

Farias

et al. 2024

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Chemical profile and biological activity of Crinum americanum L. (Amaryllidaceae)

Cited by 9 publications

References 48 publications

Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

Sustainable approaches for the study of alkaloids from plants using supercritical fluid-based processes

Anti-diabetic, antiglycant, antioxidant, and anticancer activities of Crinum americanum L. leaves lipid fraction

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