Chemical Principles In The Design Of Improved Porphyrin Photosensitizers

Franck, Burchard; Fülling, Gerd; Gosmann, Martin; Kniibel, G.; Mertes, H.; Schröder, Doris

doi:10.1117/12.960192

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1991

1992

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“…We were interested in the photochemical transformation of MC540 1 in connection with our investigations on PDT applications of novel vinylogous porphyrins (Franck et al, 1988;Beckmann et al, *To whom correspondence should be addressed. ?Abbreviations: FT-IR, Fourier transform infrared; MC540, merocyanine 540; MS, mass spectroscopy; lo2, singlet oxygen; PDT, photodynamic therapy; RB, Rose Bengal; TLC, thin layer chromatography.…”

Section: Introductionmentioning

confidence: 99%

Photooxidation Products of Merocyanine 540 Formed Under Preactivation Conditions for Tumor Therapy

Franck

Schneider

1992

Photochem & Photobiology

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In order to gain insight into the preactivation of merocyanine 540 (MC540) 1 for the photodynamic therapy (Gulliya et al., 1990a, Photochem. Photobiol. 52, 831-838) its photo-oxidation was investigated. After irradiation of MC540 1 on a preparative scale three main photodegradation products were isolated with 16-20% yields. They turned out to be derivatives of benzoxazole, thiouracil and thiohydantoin with the structures 4, 5 and 6, respectively. It may be possible that they contribute to the cytostatic and antiviral activity of preactivated MC540 1.

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Section: Introductionmentioning

confidence: 99%