Chemical Pathology of Diseases Involving Myelin

Norton, William T.; Cammer, Wendy

doi:10.1007/978-1-4615-7514-6_11

Cited by 26 publications

(2 citation statements)

References 101 publications

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“…Conversely, axonal neuropathy may lead to secondary paranodal demyelination 37. Whereas it is well known that the distal portion of a sectioned nerve undergoes secondary demyelination as a result of axonal degeneration,38 the mechanism of paranodal segmental demyelination from localised changes or diffuse metabolic insults is less well understood. Various postulates have been put forward, ranging from hypotheses akin to pre-wallerian degeneration mechanisms39 to local processes causing a reduction in volume of the axon cylinder with disturbed ultrastructure of transport organelles 40…”

Section: Discussionmentioning

confidence: 99%

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Mills

1999

Journal of Neurology, Neurosurgery & Psychiatry

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Objective-To determine the presence and role of proximal conduction block in neuralgic amyotrophy. Methods-Percutaneous electrical stimulation of cervical roots and brachial plexus was employed in eight patients with neuralgic amyotrophy. Root to Erb's point compound muscle action potential amplitude ratios for abductor digiti minimi, extensor digitorum communis, biceps, and deltoid muscles were compared with results obtained from 10 healthy controls. Results-Conduction block in the nerve to one muscle was found in three of eight patients (38%) suggesting focal proximal demyelination. Repeat studies showed axonal degeneration, resolution, and persistence of conduction block in these three patients respectively. Conclusion-Focal conduction block plays a significant part in the pathogenesis of neuralgic amyotrophy, which is generally regarded as an axon loss process. Therapeutic intervention should be directed to patients with persistent conduction block, with the aim of eradicating the block and possibly minimising subsequent axon loss. (J Neurol Neurosurg Psychiatry 1999;66:586-590)

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Section: Discussionmentioning

confidence: 99%

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Mills

1999

Journal of Neurology, Neurosurgery & Psychiatry

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“…The classical form of the disease has a later onset and slower progression, and patients may live up to 30 years. All cases of PMD do not fall unequivocally into one category or the other because there appears to be a spectrum of Ievels of severity (Hudson and Nadon, 1990;Raine, 1984b;Norton and Cammer, 1984).…”

Section: Pelizaeus-merzbacher Diseasementioning

confidence: 99%

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

Driscoll¹

1992

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Partition coefficients of 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) in erythrocyte lipids in multiple sclerosis

Berner

Blanco

Ellison

et al. 1980

J of Neuroscience Research

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Electron spin resonance (ESR) was used in a search for a possible generalized membrane defect underlying myelin instability in multiple sclerosis (MS). In contrast to most ESR studies of biological membranes, a small, nonelectrolyte spin label, TEMPO, was chosen; its partition coefficient was determined in extracted erythrocyte lipids from MS patients and normal controls. No differences were observed the advantages and limitations of TEMPO in comparison with lipid spin labels as probes for the study of biological membranes are discussed.

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Chemical Pathology of Diseases Involving Myelin

Cited by 26 publications

References 101 publications

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

Partition coefficients of 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) in erythrocyte lipids in multiple sclerosis

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