Chemical oxidation and reduction of hexachlorocyclohexanes: A review

Wacławek, Stanislaw; Silvestri, Daniele; Hrabák, Pavel; Padil, Vinod V.T.; Torres–Mendieta, Rafael; Wacławek, Maria; Černík, Miroslav; Dionysiou, Dionysios D.

doi:10.1016/j.watres.2019.06.072

Cited by 86 publications

(24 citation statements)

References 192 publications

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“…For this purpose, removal and bio-degradative strategies should be investigated pointing towards the intrinsic and environmental resilience of β-HCH as major burden. Since several HCH-degrading systems have already been identified in particular for the γ-isomer [39], in the future they may also be applied to β-HCH.…”

Section: Discussionmentioning

confidence: 99%

β-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry

et al. 2020

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Organochlorine pesticides (OCPs) belong to a heterogeneous class of organic compounds blacklisted by the Stockholm Convention in 2009 due to their harmful impact on human health. Among OCPs, β-hexachlorocyclohexane (β-HCH) is one of the most widespread and, at the same time, poorly studied environmental contaminant. Due to its physicochemical properties, β-HCH is the most hazardous of all HCH isomers; therefore, clarifying the mechanisms underlying its molecular action could provide further elements to draw the biochemical profile of this OCP. For this purpose, LNCaP and HepG2 cell lines were used as models and were subjected to immunoblot, immunofluorescence, and RT-qPCR analysis to follow the expression and mRNA levels, together with the distribution, of key biomolecules involved in the intracellular responses to β-HCH. In parallel, variations in redox homeostasis and cellular bioenergetic profile were monitored to have a complete overview of β-HCH effects. Obtained results strongly support the hypothesis that β-HCH could be an endocrine disrupting chemical as well as an activator of AhR signaling, promoting the establishment of an oxidative stress condition and a cellular metabolic shift toward aerobic glycolysis. In this altered context, β-HCH can also induce DNA damage through H2AX phosphorylation, demonstrating its multifaceted mechanisms of action.

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Section: Discussionmentioning

confidence: 99%

β-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry

et al. 2020

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“…The combination of steps results in complete dechlorination without the accumulation of persistant halogenated byproducts such as the dichloroethenes from trichloroethylene or chloroform from carbon tetrachloride. Other contaminants with analogous chemical structures to TCP range from 1,2-dichloroethane (1,2-DCA) 32,86 to hexachlorocyclohexane (HCH, including lindane), 87,88 so further analysis of their environmental fate might benet from application of the computational methods and analysis developed here for TCP.…”

Section: Discussionmentioning

confidence: 99%

Reduction of 1,2,3-trichloropropane (TCP): pathways and mechanisms from computational chemistry calculations

Torralba–Sanchez

Bylaska

Salter-Blanc

et al. 2020

Environ. Sci.: Processes Impacts

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“…A range of treatment technologies have been suggested for HCH-contaminated areas, and numerous studies focused on the chemical reduction and degradation of HCH isomers have been undertaken [9][10][11][12][13]. Over the last decade, however, increasing attention has been paid to the use of carbon-rich materials, such as charcoal, bio-coal, and activated carbon, for stabilizing organic pollutants in sediments and soils in situ [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

HCH Removal in a Biochar-Amended Biofilter

Amirbekov

Mamirova²,

Ševců

et al. 2021

Water

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This study evaluated the efficiency of two biofilter systems, with and without biochar chambers installed, at degrading and removing HCH and its isomers in natural drainage water. The biochar biofilter proved to be 96% efficient at cleaning HCH and its transformation products from drainage water, a significant improvement over classic biofilter that remove, on average, 68% of HCH. Although iron- and sulfur-oxidizing bacteria, such as Gallionella and Sulfuricurvum, were dominant in the biochar bed outflows, they were absent in sediments, which were rich in Simplicispira, Rhodoluna, Rhodoferax, and Flavobacterium. The presence of functional genes involved in the biodegradation of HCH isomers and their byproducts was confirmed in both systems. The high effectiveness of the biochar biofilter displayed in this study should further encourage the use of biochar in water treatment solutions, e.g., for temporary water purification installations during the construction of other long-term wastewater treatment technologies, or even as final solutions at contaminated sites.

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Chemical oxidation and reduction of hexachlorocyclohexanes: A review

Cited by 86 publications

References 192 publications

β-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry

β-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry

Reduction of 1,2,3-trichloropropane (TCP): pathways and mechanisms from computational chemistry calculations

HCH Removal in a Biochar-Amended Biofilter

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