Chemical modifications and transformations of 3-azahetarylchroman-4-ones

Abstract

Articles reporting on the chemical modifications and transformations of 3-azahetarylchroman-4-ones are rewieved. The following 3-azahetarylchroman-4-ones’ transformation - reduction of 3-azahetarylchromon-4-ones to the corresponding 3-azahetarylchromanols, -chromenes, and -3,4-dihydrochromenes, alkylation of 3-azahetarylchromanols, reconversion into 3-azahetarylchromones, formation of 3-hetarylchroman-4-one oximes and corresponding oxime ethers, recyclization into 3-aryl-4-hetarylpyrazolines are described. The biological activity of 3-azahetarylchroman-4-one modification or transformation products are also adduced.

Synthesis and biological activity of 3-azahetarylchroman-4-ones

“…The researches that have been reported on the 3-hetarylchromones are both extensive and varied [1][2][3][4]. The hydrogenated chromone derivatives are of indubitable interest, owing to a wide spectrum of biological activity (estrogenic, anti-cancer, antiinflammatory, antioxidative, hepatoprotective, antimicrobial, hypolipidemic etc.)…”