Chemical modification of silk fibroin with N-acetyl-chito-oligosaccharides

Silk proteins for biomedical applications: Bioengineering perspectives

“…The functionalized silk conjugate acts as an effective bone-inducing matrix in vitro, demonstrating higher osteoblast adhesion and overall calcification, when compared to other tested matrices. A method of arginine masking in fibroin (conversion to imidazolidinone) minimizes the interactions of positively-charged residues with other chemical species, thereby improving compatibility as cell culture substrata [42].…”

Structure and properties of regenerated Antheraea pernyi silk fibroin in aqueous solution

“…It is different with that of B. mori silk fibroin. The molecular conformation of B. mori silk fibroin in aqueous solution is almost random coil [23][24][25][26].…”

Preparation and characterization of fibroin/hyaluronic acid composite scaffold

“…It is an attractive natural fibrous protein for biomedical applications due to its permeability to oxygen and water, cell adhesion and growth characteristics, relatively low thrombogenicity, low inflammatory response, protease susceptibility and high tensile strength with flexibility. Recent studies have explored the use of fibroin, especially in the biomedical field as a substrate for a wound dressing [1,2], an antithrombogenic material [3,4], a cell culture substrate [5][6][7][8][9], a bone-compatible material [10][11][12], or as a scaffold for anterior cruciate ligament regeneration [13]. Silk fibroin was proved to have good neural biocompatibility and to be a candidate material for neural tissue engineering applications [14,15].…”