Chemical Modification of Polysaccharides: A Review of Synthetic Approaches, Biological Activity and the Structure–Activity Relationship

Liu, Tianbo; Ren, Qiushi; Wang, Shuang; Gao, Jia-Ning; Shen, Congcong; Wang, Yanhong; Guan, Feng

doi:10.3390/molecules28166073

Cited by 22 publications

(8 citation statements)

References 102 publications

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“…Polysaccharides, due to their versatility with numerous reactive functional groups such as hydroxyl, amino, and carboxyl, are highly adaptable to chemical reactions that introduce new groups into their structure . Any modification or additive introduced in the manufacturing process carries the potential to impact the degradability of materials, alter the nature of decomposition products, and ultimately shape the environmental destiny of the product.…”

Section: Bioplasticsmentioning

confidence: 99%

Embracing Nature’s Clockwork: Crafting Plastics for Degradation in Plant Agricultural Systems

Merino

2024

ACS Mater. Au

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In the 21st century, global agriculture confronts the urgent challenge of increasing food production by 70% by 2050 while simultaneously addressing environmental and health concerns. Plastics, integral to agricultural innovation, present sustainability challenges due to their non-biodegradable nature and contribution to pollution. This perspective examines the transition to bioplastics, emphasizing their bio-based origin and their crucial characteristic of being readily biodegradable in the soil. Key bioplastics such as poly(lactic acid) (PLA), polyhydroxyalkanoates (PHAs), and biomass-derived polymers are discussed, particularly regarding the microplastic generation in soil resulting from their use in specific applications like mulch films, delivery systems, and soil conditioners. Embracing bioplastics signifies a significant step forward in achieving sustainable agriculture and addressing plastic waste. However, it is highlighted that while some bioplastics can be recovered and recycled, special applications where the plastic is in intimate contact with soil pose challenges for recovery. In these cases, that represent more than the 50% of plastics used in agriculture, meticulous design for biodegradation in soil synchronized with agricultural cycles is necessary. This approach ensures minimal environmental impact and promotes a circular approach to plastic use in agriculture.

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Section: Bioplasticsmentioning

confidence: 99%

Embracing Nature’s Clockwork: Crafting Plastics for Degradation in Plant Agricultural Systems

Merino

2024

ACS Mater. Au

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“…In recent studies, it has been observed to enhance the proliferation of embryonic stem cells and demonstrate anticoagulant properties [ 28 , 29 ]. Numerous studies indicate that the inherent bioactivities of native polysaccharides are relatively low but can be significantly improved through molecular modifications [ 30 ]. Sulfation or carboxymethylation emerges as a viable approach to address the limited water solubility and amplify the biological activity of natural polysaccharides through the alteration of their structural and conformational characteristics [ 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Carboxymethylated and Sulfated Furcellaran from Furcellaria lumbricalis and Its Immobilization on PLA Scaffolds

Štěpánková,

Ozaltin,

Sáha

et al. 2024

Polymers

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This study involved the creation of highly porous PLA scaffolds through the porogen/leaching method, utilizing polyethylene glycol as a porogen with a 75% mass ratio. The outcome achieved a highly interconnected porous structure with a thickness of 25 μm. To activate the scaffold’s surface and improve its hydrophilicity, radiofrequency (RF) air plasma treatment was employed. Subsequently, furcellaran subjected to sulfation or carboxymethylation was deposited onto the RF plasma treated surfaces with the intention of improving bioactivity. Surface roughness and water wettability experienced enhancement following the surface modification. The incorporation of sulfate/carboxymethyl group (DS = 0.8; 0.3, respectively) is confirmed by elemental analysis and FT-IR. Successful functionalization of PLA scaffolds was validated by SEM and XPS analysis, showing changes in topography and increases in characteristic elements (N, S, Na) for sulfated (SF) and carboxymethylated (CMF). Cytocompatibility was evaluated by using mouse embryonic fibroblast cells (NIH/3T3).

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“…Moreover, natural compounds can undergo chemical modifications to bolster their potency, selectivity, and pharmacokinetic properties [18,19]. Medicinal chemists employ techniques like structure-activity relationship (SAR) studies and combinatorial chemistry to design and synthesize analogs with enhanced anticancer activity [20,21].…”

Section: Introductionmentioning

confidence: 99%

Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells

Nishimura,

Sampaio,

Komoto

et al. 2024

IJMS

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Breast cancer stands out as one of the most prevalent malignancies worldwide, necessitating a nuanced understanding of its molecular underpinnings for effective treatment. Hormone receptors in breast cancer cells substantially influence treatment strategies, dictating therapeutic approaches in clinical settings, serving as a guide for drug development, and aiming to enhance treatment specificity and efficacy. Natural compounds, such as curcumin, offer a diverse array of chemical structures with promising therapeutic potential. Despite curcumin’s benefits, challenges like poor solubility and rapid metabolism have spurred the exploration of analogs. Here, we evaluated the efficacy of the curcumin analog NC2603 to induce cell cycle arrest in MCF-7 breast cancer cells and explored its molecular mechanisms. Our findings reveal potent inhibition of cell viability (IC50 = 5.6 μM) and greater specificity than doxorubicin toward MCF-7 vs. non-cancer HaCaT cells. Transcriptome analysis identified 12,055 modulated genes, most notably upregulation of GADD45A and downregulation of ESR1, implicating CDKN1A-mediated regulation of proliferation and cell cycle genes. We hypothesize that the curcumin analog by inducing GADD45A expression and repressing ESR1, triggers the expression of CDKN1A, which in turn downregulates the expression of many important genes of proliferation and the cell cycle. These insights advance our understanding of curcumin analogs’ therapeutic potential, highlighting not just their role in treatment, but also the molecular pathways involved in their activity toward breast cancer cells.

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Chemical Modification of Polysaccharides: A Review of Synthetic Approaches, Biological Activity and the Structure–Activity Relationship

Cited by 22 publications

References 102 publications

Embracing Nature’s Clockwork: Crafting Plastics for Degradation in Plant Agricultural Systems

Embracing Nature’s Clockwork: Crafting Plastics for Degradation in Plant Agricultural Systems

Carboxymethylated and Sulfated Furcellaran from Furcellaria lumbricalis and Its Immobilization on PLA Scaffolds

Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells

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