Pharmaceuticals and many other chemicals are an important basis for nearly all sectors including for example, food and agriculture, medicine, plastics, electronics, transport, communication, and many other products used nowadays. This comes along with a tremendous chemicalization of the globe, including ubiquitous presence of products of chemical and pharmaceutical industries in the aquatic environment. Use of these products will increase with population growth and living standard as will the need for clean water. In addition, climate change will exacerbate availability of water in sufficient quantity and quality. Since its implementation, conventional wastewater treatment has increasingly contributed to environmental protection and health of humans. However, with the increasing pollution of water by chemicals, conventional treatment turned out to be insufficient. It was also found that advanced effluent treatment methods such as extended filtration, the sorption to activated charcoal or advanced oxidation methods have their own limitations. These are, for example, increased demand for energy and hazardous chemicals, incomplete or even no removal of pollutants, the generation of unwanted products from parent compounds (transformation products, TPs) of often-unknown chemical structure, fate and toxicity. In many countries, effluent treatment is available only rarely if at all let alone advanced treatment. The past should teach us, that focusing only on technological approaches is not constructive for a sustainable water quality control. Therefore, in addition to conventional and advanced treatment optimization more emphasis on input prevention is urgently needed, including more and better control of what is present in the source