Chemical metabolome assay by high‐resolution Orbitrap mass spectrometry and assessment of associated antitumoral activity of <i>Actinocephalus divaricatus</i>

Zanatta, Ana C.; Mari, Angela; Masullo, Milena; Carlos, Iracilda Zeppone; Vilegas, Wagner; Piacente, Sonia; Santos, Lourdes Campaner dos

doi:10.1002/rcm.8034

Cited by 10 publications

(7 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their structures were determined by spectroscopic and spectrometric techniques [ 23 ]. Additionally, the naphthopyranones 134 and 136 were identified in aerial parts of Actinocephalus divaricatus by high-resolution orbitrap mass spectrometry [ 79 ]. Compounds 134 , 135 , and 136 were also isolated in the whole Eriocaulon buergerianum species [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

“…In antioxidant assay, compounds 151 and 152 showed the highest TEAC values [ 61 ]. The naphthopyranones 151 and 152 were identified in aerial parts of Actinocephalus divaricatus by high-resolution orbitrap mass spectrometry [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

“…Compound 155 was also isolated from Actinocephalus divaricatus (Körn.) Sano methanolic extract [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

et al. 2022

View full text Add to dashboard Cite

Eriocaulaceae is a pantropical family whose main center of biodiversity is in Brazil. In general, the family has about 1200 species, in which phytochemical and biological studies have shown a variety of structures and activities. The aim of this research is to compile the compounds isolated in the Eriocaulaceae family and carry out a computational study on their biological targets. The bibliographic research was carried out on six databases. Tables were built and organized according to the chemical class. In addition, a summary of the methods of isolating the compounds was also made. In the computational study were used ChEMBL platform, DRAGON 7.0, and the KNIME 4.4.0 software. Two hundred and twenty-two different compounds have been isolated in sixty-eight species, divided mainly into flavonoids and naphthopyranones, and minor compounds. The ligand-based virtual screening found promising molecules and molecules with multitarget potential, such as xanthones 194, 196, 200 and saponin 202, with xanthone 194 as the most promising. Several compounds with biological activities were isolated in the family, but the chemical profiles of many species are still unknown. The selected structures are a starting point for further studies to develop new antiparasitic and antiviral compounds based on natural products.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For the Q-Exactive, the Orbitrap is used for acquiring both MS and MS/MS spectra [46]. Although Orbitrap instruments have originally found great applications in proteomics analysis, where very high resolution is required, several hyphenated LTQ-Orbitrap-MS methods, mainly coupled to (U)HPLC-based techniques, have also been reported for small compounds identification [25,[47][48][49] and metabolite profiling [26,50,51], as well as for metabolome [52] or dereplication studies of natural products in complex plant extracts [27].…”

Section: Orbitrap Ms Methodsmentioning

confidence: 99%

Recent applications of high resolution mass spectrometry for the characterization of plant natural products

Álvarez-Rivera

Ballesteros-Vivas

Parada-Alfonso

et al. 2019

TrAC Trends in Analytical Chemistry

100

View full text Add to dashboard Cite

Recently, the high analytical power provided by the new HRMS instruments (working in the MS or MS/MS mode, stand alone or hyphenated with separation techniques) is making more feasible the characterization of plant secondary metabolites. In this regard, HRMS-based techniques are becoming the technique of choice, since they are capable of answering many questions regarding analytical characterization of secondary metabolites, usually found in very complex matrices, including their structure, composition and concentration in a very fast and sensitive way. In this manuscript we will provide a critical and updated revision of this topic covering the works published in the last 4 years (2015)(2016)(2017)(2018), including the different configurations in which HRMS may be used (stand alone or hyphenated), the data treatment, the strategies for the identification of unknown metabolites, the current software for structure elucidation, as well as the last trends and future outlooks in this hot area of research.

show abstract

“…There are an abundance of chemical constituents in Succus Bambusae, mainly volatile ingredients, amino acids, flavonoids, trace elements, and vitamins, which have high medicinal and edible value. Its main pharmacological actions are antitussive and expectorant, bacteriostatic and antitumor 4–6 …”

Section: Introductionmentioning

confidence: 99%

Quality assessment of Succus Bambusae oral liquids based on gas chromatography/mass spectrometry fingerprints and chemometrics

Feng

et al. 2021

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Rationale Succus Bambusae is consumed as a kind of herbal medicine and natural beverage in China. However, the current quality standards for Succus Bambusae are low and lack safety indicators, which makes it difficult to effectively guarantee its quality. Therefore, it is of great significance to study the identification and quality control technology for the product. Methods We have developed a set of qualitative and quantitative methods based on gas chromatography/mass spectrometry (GC/MS) for the analysis of volatile components in Succus Bambusae oral liquid (SBOL). Combining GC/MS fingerprint analysis and related chemometrics algorithms, with similarity evaluation, Hotelling T2 and distance to Model X (DModX) as criteria, the quality consistency of different batches was evaluated, and SBOL samples from different manufacturers were differentiated. Results Twenty‐nine volatile components were preliminarily identified from 40 batches of SBOL samples from six manufacturers, and six Q‐markers (Quality Markers) for the SBOLs were discussed and determined using GC/MS. The products from different manufacturers were distinguished using chemometrics. Conclusions The results showed that the quality of the SBOL samples from different batches and different manufacturers fluctuated greatly, which suggested that research into the raw materials and manufacturing techniques should be strengthened to improve the quality of SBOL and ensure its quality consistency.

show abstract

Chemical metabolome assay by high‐resolution Orbitrap mass spectrometry and assessment of associated antitumoral activity of Actinocephalus divaricatus

Cited by 10 publications

References 56 publications

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

Recent applications of high resolution mass spectrometry for the characterization of plant natural products

Quality assessment of Succus Bambusae oral liquids based on gas chromatography/mass spectrometry fingerprints and chemometrics

Contact Info

Product

Resources

About