Chemical Medicines as Corrosion Inhibitors

Albayati, Mustafa R.; Lgaz, Hassane; Chaouiki, Abdelkarim; Salghi, R.; Lee, H.

doi:10.1002/9781119794516.ch13

Cited by 1 publication

(2 citation statements)

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“…Therefore, the implementation of the ambroxol derivative allows to achieve the comparable values of inhibition efficiencies with those of underivatised ambroxol, but using the 30-40 times less concentrated inhibitor solution. This confirms the fact [8] that the chemical modification of pharmaceuticals improves their inhibitory properties. The availability of the source reagents (ambroxol and salicylaldehyde) and the simple synthesis protocol make the compound 2-(6,8-dibromo-3-(4-hydroxycyclohexyl)-1,2,3,4-tetrahydroquinazolin-2yl)phenol a prospective corrosion inhibitor for industrial use.…”

Section: Discussionsupporting

confidence: 82%

“…One of the active pharmaceutical ingredients, in which inhibitory activity on the corrosion of stainless steel in the acidic medium was already demonstrated [5][6][7], is ambroxol. Moreover, it was already shown [8,9] that the chemical modification of different pharmaceuticals might improve their inhibitory properties, and the usage of derivatised pharmaceutical ingredients is also a prominent research field. In the literature, there are several pieces of evidence [10] that the products of condensation of aromatic primary amines with aromatic aldehydes exhibit excellent inhibitory properties.…”

Section: Introductionmentioning

confidence: 99%

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The Inhibitory Properties of the Ambroxol Derivative on the Corrosion of Mild Steel in Hydrochloric Acid Medium

Nikolaychuk,

Biryukov,

Sharov

et al. 2024

International Journal of Corrosion

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A compound 2-(6,8-dibromo-3-(4-hydroxycyclohexyl)-1,2,3,4-tetrahydroquinazolin-2-yl)phenol was synthetised from ambroxol hydrochloride and salicylaldehyde. The structure of the compound was studied with UV, IR, Raman, and 1H NMR spectroscopy. The inhibitory ability of the synthetised compound on the corrosion of mild stainless steel EN Fe37-3FN in 0.5 M hydrochloric acid solution was studied using gravimetric and electrochemical methods, including potentiodynamic polarisation and EIS. It was shown that the inhibitory activity of the compound increases with the increase of its concentration in a solution. An addition of 3 mg/l of the compound reduces the corrosion rate by 20% and that of 400 mg/l by 85%. The data of gravimetric and electrochemical measurements coincide well. The sorption of the compound on the metal surface obeys the Langmuir adsorption isotherm, and the nature of adsorption is physical. The compound exhibits the chelating activity with both ferrous and ferric ions in the acidic solution. The synthetised compound may be a good choice for the inhibition of steel corrosion in acidic environments.

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Section: Discussionsupporting

confidence: 82%