Chemical ionization mass spectrometric determination of organic compounds in solution at the part per million level

Price, Philip C.; Martinsen, D. P.; Upham, Roger A.; Swofford, H. S.; Buttrill, S. E.

doi:10.1021/ac60351a031

Cited by 13 publications

(7 citation statements)

References 9 publications

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“…There are also considerable data available on the temperature dependence of ester Cl spectra (7), and the mechanisms of the formation of the major fragment ions have been elucidated (8) through deuterium labeling studies. Furthermore, since most esters are at least sparingly soluble in water, they may be introduced very conveniently into the Cl mass spectrometer as dilute aqueous solutions (9,10), thereby allowing precise control of the pressures of both the ester and the water reagent gas. All of these considerations, plus their widespread occurrence both in nature and in widely used chemical processes and products, led us to choose esters for this initial study of the potential analytical applications and utility of the new drift tube chemical ionization source.…”

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confidence: 99%

Drift tube chemical ionization mass spectrometry of esters

Price¹,

Swofford²,

Buttrill³

1978

Anal. Chem.

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A series of carboxylic acid esters are examined by a new technique: drift tube chemical ionization mass spectrometry. Using water as the chemical ionization reagent gas, there Is very little fragmentation of most esters at low values of E/P in the drift tube. At higher E/P, the extent of formation of analytically useful fragments is greater than can be obtained by increasing temperature or switching to methane reagent gas. As E/P is Increased, the onset of each fragment is correlated with the endothermicity of the reaction which forms it. The absence of M+ and (M -1)+ ions In water chemical ionization mass spectra increases the usefulness of the technique for assessing sample purity while the ability to induce extensive fragmentation with the drift tube enables one to obtain structural information from the same sample.

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confidence: 99%

Drift tube chemical ionization mass spectrometry of esters

Price¹,

Swofford²,

Buttrill³

1978

Anal. Chem.

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“…The modifications to our Du Pont 21-490B mass spectrometer for conventional chemical ionization work have been described in previous publications. 3,5,7 The new pulsed high-pressure source is shown in Figure 1. All parts are stainless steel except for the insulator ring, which is made of Macor machinable glass ceramic.10 The shapes of the source block and source mounting plate are such that the insulator ring is shielded from the ions, electrons, and reactive species generated within the ion source.…”

Section: Methodsmentioning

confidence: 99%

“…The equilibrium constant for reaction 8 is readily calculated from the ratio of +•( 2 ) to MH+ and the measured pressure of water in the source. It is also possible to calculate a value of the equilibrium constant for the (3,4) vides an internal check on the quality of the data. Figure 6 compares our results for the various equilibria in water with those from Kebarle's laboratory (solid lines).14 •15 The quite good agreement between the two sets of data indicates that thermochemical equilibrium is.…”

Section: Methodsmentioning

confidence: 99%

Hydrogen bonding of water to gas-phase ions. Structural and stereochemical effects in protonated phenols

Martinsen¹,

Buttrill²

1978

J. Am. Chem. Soc.

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“…It is readily available in a highly pure form, easy to handle, and inexpensive. Furthermore, dilute aqueous solutions of organic compounds can be directly injected into a Cl mass spectrometer with no prior sample preparation (6).…”

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“…We observe that difunctional compounds tend to accentuate the formation of MH+(H20)" clusters. In a previous publication (6), it was noted that variations in cluster ion peak intensities might yield structural and conformational information. An important property of difunctional compounds is the distance between functional groups.…”

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confidence: 99%