Chemical investigation on the cultures of the fungus Xylaria carpophila

Yin, Xia; Feng, Tao; Li, Zhenghui; Su, Jia; Tan, Ning‐Hua; Liu, Ji‐Kai

doi:10.1007/s13659-011-0011-y

Cited by 20 publications

(15 citation statements)

References 22 publications

(26 reference statements)

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“…They also inhibited mammalian cell growth with high potency as demonstrated in the Vero monkey cell-growth inhibition (XTT) assay for cytotoxicity with IC 50 values of 0.46 for 66 and 1.9 mg/ml for 67 [25]. Xylariaquinone A (111) showed weak cytotoxicity against four of the tests cell lines, HL-60, SMMC-7721, A-549, and MCF-7 [15]. (À)-Xylariamide A (94) was 0 and 71% lethal to brine shrimp at 20 and 200 mg/ml, respectively [33].…”

Section: Cytotoxic Activity 34 Other Activities 4 Conclusionmentioning

confidence: 99%

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ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Song

Zhai

et al. 2014

ChemInform

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Section: Cytotoxic Activity 34 Other Activities 4 Conclusionmentioning

confidence: 99%

“…Benzoquinones. (4S,5S,6S)-5,6-Epoxy-4-hydroxy-3-methoxy-5-methylcyclohexen-1-one (112) was isolated from Xylaria carpophila [15]. 101 [39].…”

Section: Cytotoxic Activity 34 Other Activities 4 Conclusionmentioning

confidence: 99%

ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Song

Zhai

et al. 2014

ChemInform

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“…Compound 1 also showed cytotoxicity against HL‐60, A‐549, MCF‐7 and SW480 with IC 50 values of 23·1, 35·7, 28·5 and 29·0 μ mol/l respectively (Yin et al . ). In contrast, it did not show activity against Plasmodium falciparum K1 (Tansuwan et al .…”

Section: Discussionmentioning

confidence: 97%

Antimicrobial activities of an oxygenated cyclohexanone derivative isolated from Amphirosellinia nigrospora JS-1675 against various plant pathogenic bacteria and fungi

Nguyen

Kim

et al. 2019

J Appl Microbiol

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Aims To evaluate the antimicrobial activities of an active compound isolated from the culture broth of Amphirosellinia nigrospora JS‐1675 against various plant pathogenic bacteria and fungi. Methods and Results While screening for bioactive secondary metabolites from endophytic fungi, we found that A. nigrospora JS‐1675 showed strong in vitro antibacterial activity against Ralstonia solanacearum. One compound (1) was isolated and identified as (4S, 5S, 6S)‐5,6‐epoxy‐4‐hydroxy‐3‐methoxy‐5‐methyl‐cyclohex‐2‐en‐1‐one. Growth of most of the tested phytopathogenic bacteria was inhibited by compound 1 and the ethyl acetate (EtOAc) layer except Pseudomonas syringae pv. lachrymans. Compound 1 also inhibited the mycelial growth of several plant pathogenic fungi. Both compound 1 and the EtOAc layer reduced bacterial leaf spot disease in detached peach leaves. They also suppressed the development of bacterial wilt on tomato seedlings quite effectively. Conclusions Amphirosellinia nigrospora JS‐1675 showed antimicrobial activity against plant pathogenic bacteria and fungi by producing compound 1. Significance and Impact of the Study This is the first report on the occurrence of compound 1 in A. nigrospora JS‐1675 and its efficacy against plant pathogenic bacteria and fungi. Their strong disease control efficacy against tomato bacterial wilt suggests that this fungus can be used as a microbial bactericide.

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“…Driman-7a,8a,11-triol has been synthesized in diastereomerically pure form. 84 Another three compounds of this type 105-107 have been found in extracts of fungal endophytes, which had been isolated from Pinus strobus. 83 5 Bisabolane, macrocarpane, sesquithujene and heliannane group Xylacarpins D 103 and E 104 are two new bisabolane derivatives, which have been obtained from cultures of the fungus Xylaria carpophila.…”

Section: Bicyclofarnesanementioning

confidence: 99%

“…122 Another species of this genus, Laurencia dendroidea, contains several chamigrane sesquiterpenes with leishmanicidal activity. 84 A goldand copper-catalyzed cycloisomerization has been used in the synthesis of thujopsane-like compounds. 124 The thujopsane derivatives xylcarpins C-E 147-149 have been isolated from cultures of the fungus Xylaria carpophila.…”

Section: Chamigrane and Thujopsanementioning

confidence: 99%