Chemical investigation of the herbage ofMelissa officinalis

Куркин, В. А.; Kurkina, T. V.; Zapesochnaya, G. G.; Авдеева, Е В; Bogolyubova, Zh. V.; Vandyshev, V. V.; Chikina, I. Yu.

doi:10.1007/bf01170225

Cited by 3 publications

(2 citation statements)

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“…The content of essential oil was reported to be highest in the apical leaves and lowest in the basal leaves of lemon balm [1], [9], [10]. A basipetal decrease of oil content was observed in our herb samples ( Table 1).…”

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confidence: 47%

The Influence of the Harvest Cut Height on the Quality of the Herbal Drugs Melissae folium and Melissae herba

Tekeľová

Felklová

et al. 2002

Planta med

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Variability in both the content and quality of essential oil was observed in herb and leaf drugs in dependence on the harvest cut height of lemon balm (Melissa officinalis L. cv. Citra). Three different cuts were carried out on the respective plants. The oil content in the herb was highest in the top third (0.13 % V/m), satisfactory in the herb including both the top and middle thirds (0.08 % V/m) and lowest in the whole herb (0.06 % V/m). The oil content in the leaves of the respective herbs was in the range 0.39 % - 0.14 % V/m (top third part - whole aerial part). The percentage of citrals, linalool and beta-caryophyllene in essential oil decreased in the basipetal direction, whilst the amounts of beta-caryophyllene oxide and citronellal increased in the same direction. Citrals (A and B): 55.79 % in the top third part of the herb, 48.46 % in the whole herb, 59.74 % and 56.87 % in the leaves from that parts, respectively. Similarly, beta-caryophyllene: 5.01 %, 3.87 %, 6.97 %, 5.13 %; beta-caryophyllene oxide: 17.19 %, 24.07 %, 15.64 %, 17.82 %; citronellal: 2.73 %, 5.51 %, 2.82 %, 6.44 %.

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mentioning

confidence: 47%

The Influence of the Harvest Cut Height on the Quality of the Herbal Drugs Melissae folium and Melissae herba

Tekeľová

Felklová

et al. 2002

Planta med

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“…These classes of phenolic compounds have already been described to occur in Melissa officinalis total extracts. Kurkin et al (Chem Natural Compounds 1995) [18] isolated and identified rosmarinic acid, ethyl rosmarinate and caffeic acid as phenylpropanoid derivatives and luteolin and apigenin glycosides as flavone derivatives. However, no flavonol derivative had been so far described for Melissa officinalis aqueous extract (see summary in Table 3).…”

Section: Hplc-dad Analysis Of the Compounds Of The Total Aqueous Extractmentioning

confidence: 99%

Genotoxic and Mutagenic Effects of Melissa officinalis (Erva Cidreira) Extracts

Alves¹,

Vidal²,

Küster³

et al. 2009

TOTOXIJ

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Erva cidreira (Melissa officinalis) is a plant with sedative properties and in Brazil it has been used for insomnia and anxiety. It is also employed to stimulate liver functions and normalize menstruation and for intestinal constipation. The aim of this work was to evaluate the genotoxic and mutagenic effects of erva cidreira. Results indicate the presence of genotoxic activity in the lyophilized extract, with lysogenic induction increasing about 80-fold over the spontaneous background after treatment with lyophilized total aqueous extract. Beta-galactosidase levels raised 9-fold in indicator strains after treatment under the same conditions. A deeper look into the mechanism underlying the genotoxic action implicated reactive oxygen species generated by compounds retained in the ethyl-acetate, polar partition of the total aqueous extract. The spectrum of mutations revealed a great trend for base substitutions, mainly in guanines and adenines. The presence of phenolic compounds, especially caffeic acid derivatives, may be correlated to its genotoxic activity. We thus conclude that compounds present in current concentrations of erva cidreira extracts are genotoxic and mutagenic, and might have carcinogenic potential.

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