Chemical investigation of<b><i>Finlaysonia obovata</i></b>: part I  – a rare triterpene acid showing antibacterial activity against fish pathogens

Mishra, Pravat Manjari; Sree, A.

doi:10.1080/14786410701640403

Cited by 8 publications

(7 citation statements)

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“…Finlaysonia obovata (family: Periplocaceae) is a latex‐exuding mangrove plant abundantly found in the tidal flats in India, Burma, and Malay, the leaves of which are used in salad and treatment of asthma . A number of triterpenes and steroids were isolated from this plant . The nonpolar extract (hexane extract) of this plant has shown very good antibacterial activity against fish and human bacterial pathogens .…”

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confidence: 99%

Finlaysonia obovata—A renewable resource of plant hydrocarbons

Mishra

Sree

2014

Env Prog and Sustain Energy

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Because of the increased demand and depletion of fossil hydrocarbons, the researchers have now started to pay attention toward exploitation of new energy plants and biomass of plants as alternate source of fuels and petrochemicals. Mangroves which possess enormous economic potential and utilitarian value in the ecosystem are very promising as energy plants, because they are fast growing and most of them contain abundant fatty acids, hydrocarbons, and so forth. In this article, the isolation of a white waxy amorphous solid from the hexane extract of leaves of Finlaysonia obovata is described, a mangrove plant which was found to be a mixture of saturated straight-chain, branched-chain, and long-chain linear aliphatic hydrocarbons by gas chromatography-mass spectrometry analysis. The waxy solid showed the existence of hydrocarbons ranging from 8 to 30 carbon atoms. The waxy solid contains more than 70% of linear saturated long-chain hydrocarbons. Among the saturated hydrocarbons, the content of docosane and pentacosane were found to be the major ones. The other major saturated hydrocarbons are tetradecane, hexadecane, and triacontane. Its high carbon content (85-90%) and absence of nitrogen and oxygen indicates its good fuel quality. The similarity of physical/ spectral characteristics of the waxy component with other renewable sources of hydrocarbons from the literature is discussed, and the results obtained are very promising.

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Section: Introductionmentioning

confidence: 99%

Finlaysonia obovata—A renewable resource of plant hydrocarbons

Mishra

Sree

2014

Env Prog and Sustain Energy

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“…Earlier we have studied the antibacterial activity, performed the GCMS analysis of extracts, studied the lipids of the leaf, and isolated a rare antibacterial triterpene from F. obovata [2,3]. The present paper deals with the antibacterial screening of column fractions of an active hexane extract, and isolation and spectral characterization of stigmast-4-en-3β-ol from leaves of F. obovata.The antibacterial assay of the hexane extract of leaves of F. obovata was carried out against seven freshwater fish pathogenic bacteria (see Experimental) [3]. The hexane extract was found active against all except S. aureus and E. tarda.…”

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“…Mangrove latex-bearing plants were found to show antibacterial and antiviral activity [1]. Earlier we have studied the antibacterial activity, performed the GCMS analysis of extracts, studied the lipids of the leaf, and isolated a rare antibacterial triterpene from F. obovata [2,3]. The present paper deals with the antibacterial screening of column fractions of an active hexane extract, and isolation and spectral characterization of stigmast-4-en-3β-ol from leaves of F. obovata.…”

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Chemical investigation and antibacterial study of hexane extract of leaves of Finlaysonia obovata

Mishra

Sree

2009

Chem Nat Compd

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Finlaysonia obovata, a latex -exuding mangrove plant (Fam. Periplocaceae), is found in the tidal flats in India, Burma, and Malay, the leaves of which are reported to be eaten as salad in the Moluccas. Mangrove latex-bearing plants were found to show antibacterial and antiviral activity [1]. Earlier we have studied the antibacterial activity, performed the GCMS analysis of extracts, studied the lipids of the leaf, and isolated a rare antibacterial triterpene from F. obovata [2,3]. The present paper deals with the antibacterial screening of column fractions of an active hexane extract, and isolation and spectral characterization of stigmast-4-en-3β-ol from leaves of F. obovata.The antibacterial assay of the hexane extract of leaves of F. obovata was carried out against seven freshwater fish pathogenic bacteria (see Experimental) [3]. The hexane extract was found active against all except S. aureus and E. tarda. This extract was further taken up for fractionations and isolations of secondary metabolites. The results of anti-pathogenic screening of the active column fraction of the hexane extract [compound 2 is isolated] are presented in Table1. The column fraction (EtOAc:hexane-1:9) showed activity against S. aureus, which clearly proves the enrichment of the active components during fractionation.Column chromatography of the hexane extract over silica gel yielded two compounds 1, 2, which were identified by color reactions, TLC, IR, and preparation of acetates. Fraction 1 (hexane-EtOAc, 9.7:0.3) eluate, on crystallization from ethyl acetate, afforded a crystalline solid, lupeol acetate (1).Fraction 2 (hexane-EtOAc, 9:1), after purification and after repeated crystallization from methanol, yielded a white crystalline compound 2, mp 122-123°C. It gave a positive Liebermann-Burchard test for steroids. Also it gave a purple color with acid spray, which indicated that 2 might be a sterol.

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“…Earlier, the antibacterial assay of the hexane extract of F. obovata was studied by us against seven freshwater fish pathogenic bacteria [8]. The hexane extract was found active against five tested pathogens.…”

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confidence: 99%