Chemical Investigation and Anti-Inflammatory Activity of Vitex negundo Seeds

Chawla, Amit Kumar; Sharma, Abhıshek; Handa, S. S.; Dhar, K.L.

doi:10.1021/np50080a002

Cited by 91 publications

(51 citation statements)

References 5 publications

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“…The phytochemical present in the leaf extract such as Flavonoids [38][39][40] iridoids [41][42][43], terpenes [44,45], and steroids [46] are the major classes of compounds isolated from this plant. Terpenoids are poorly water-soluble and hence may not be among prime moieties involved in the bioreduction reaction.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles Using Vitex negundo (Karu Nochchi) Leaf Extract and its Antibacterial Activity

alakshmi¹,

Venugobal²

2017

Med chem

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The present paper focuses on the synthesis of silver nanoparticles using with different leaf extract concentrations of Vitex negundo. The biosynthesized nanoparticles were characterized by UV-vis absorption spectrophotometry, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy dispersive X-ray, atomic force microscopy, transmission electron microscopy, photoluminescence and zeta potential techniques. The formation of silver nanoparticles was confirmed by the surface plasmon resonance absorption peak at 423 nm in UV-vis absorption spectra of the synthesized silver nanoparticles. The fourier transform infrared spectroscopy indicates flavonoids as a potential reduced agents. Field emission scanning electron microscopy shows the synthesized silver nanoparticles are in spherical shape. Energy dispersive X-ray spectroscopy shows the strong peak belongs to silver, and it confirms the formation of Ag NPs. X-ray diffraction spectra of synthesized silver nanoparticles exhibit they are in face centered cubic crystalline structure. The photoluminescence spectra of synthesized silver nanoparticles show their emission peak at 489-481 nm and the emission intensity is proportional to the different concentrations of leaf extract. The spherical shaped silver nanoparticles are observed by atomic force microscopy technique. The zeta potential value is observed at -13.5 mV, which shows the synthesized silver nanoparticles are incipient instability. The antimicrobial activity of the synthesized nanoparticles is studied using the disc diffusion method, which indicates that both Gram positive and Gram negative microorganisms have been affected by the silver nanoparticles. The observed antibacterial activity could be find important applications in medicine, biology and industry.

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Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles Using Vitex negundo (Karu Nochchi) Leaf Extract and its Antibacterial Activity

alakshmi¹,

Venugobal²

2017

Med chem

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“…It has significant productive effect on glycoprotein metabolism [9]. Experiments have demonstrated that different parts of the plant especially leaves, fruits, roots and seeds possess anti-inflammatory and anti-arthritic activity [10][11][12][13][14].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Estimation of Micronutrients in <i>Vitex negundo</i> L. (Karunochi) Leaves

Devi

Rani

Theivaprakasham

et al. 2016

FoodSci: Indian Journal of Research in Food Science and Nutrition

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“…Many species have been studied in relation their chemistry, which is characterized by the presence of C-glucosyl fl avones, ecdysteroids, diterpenes and iridoids (Brito, 1992), as well as in relation to their biological activities. Antiinfl ammatory (Sidhartha et al, 1990;Chawla, et al, 1991), wound healing (Sidhartha et al, 1990) and antiandrogenic (Bhargava, 1989) activities, as well as inhibition of lymphocyte proliferation (You et al, 1998) and smooth muscle relaxant effect (Dayrit et al, 1987;Dayrit & Lagurin, 1994) are among those described in literature. V. agnus-castus is actually used in the treatment of pre-menstrual syndrome and menopausal complaints (Mills & Bone, 2000).…”

Section: Introductionmentioning

confidence: 96%

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

Leitão¹,

Santos²,

Monachè³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Vitex cymosa Bertero ex Spreng., Lamiaceae, is found in Central and Amazon regions of Brazil, where it is popularly used as antirheumatic. Extracts from the leaves of V. cymosa were tested in analgesia models such as abdominal contortions induced by acetic acid and formalin to test peripheral analgesia; as well as the tail flick and hot plate models, to test spinal and supraspinal analgesia. A significant reduction was observed in the number of contortions with all extracts and in all doses. In the formalin model, a reduction in the second phase (inflammatory) was observed with all extracts, whereas only the n-butanol extract was able to act in the first, neurogenic, phase. In the tail flick model, all extracts increased latency time. Naloxone treatment reverted analgesic effect of all extracts with the exception of the dichloromethane one. All extracts developed peripheral and central analgesic activity. In the hot plate model no antinociceptive effect was observed for all tested extracts. All these results taken together suggest that V. cymosa leaf extracts were able to promote peripheral and central antinociceptive activity mediated by the opioid system.Twenty three substances were isolated and identified in the extracts and include flavonoids (C-glucosyl flavones, flavones and flavonols), triterpene acids from ursane and oleanane types, iridoids (free and glucosides), as well as simple phenols.

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Chemical Investigation and Anti-Inflammatory Activity of Vitex negundo Seeds

Cited by 91 publications

References 5 publications

Green Synthesis and Characterization of Silver Nanoparticles Using Vitex negundo (Karu Nochchi) Leaf Extract and its Antibacterial Activity

Green Synthesis and Characterization of Silver Nanoparticles Using Vitex negundo (Karu Nochchi) Leaf Extract and its Antibacterial Activity

Estimation of Micronutrients in <i>Vitex negundo</i> L. (Karunochi) Leaves

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

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