“…The experimental charge density analysis, based on lowtemperature high-resolution X-ray diffraction, is a reliable tool for the study of both inter-and intra-molecular interactions in crystalline solid state materials (Koritsanszky et al, 1998;Koritsanszky & Coppens, 2001;Jelsch et al, 1998;Lecomte et al, 2004;Fournier et al, 2009;Stalke & Ott, 2008). To predict the nature of chemical bonding in any molecule, to precisely evaluate the interactions between drug and receptor sites and understand molecular recognition at electronic level, charge density analysis provides the ultimate solution (Housset et al, 2000;Muzet et al, 2003;Li et al, 2002;Grabowsky et al, 2009;Destro et al, 2005;Flaig et al, 2001;Guillot et al, 2001;Stalke, 2011;Flierler et al, 2011). The knowledge of charge density distribution is valuable for drug designing through crystal engineering approaches (Duggirala et al, 2016).…”