2017
DOI: 10.1021/acschembio.7b00388
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Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin

Abstract: A polyether antibiotic, ecteinamycin (1), was isolated from a marine Actinomadura sp., cultivated from the ascidian Ecteinascidia turbinata. 13C enrichment, high resolution NMR spectroscopy, and molecular modeling enabled elucidation of the structure of 1, which was validated on the basis of comparisons with its recently reported crystal structure. Importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of Clostridium difficile NAP1/B1/027 (MIC = 59 ng/μL), as well as other toxigeni… Show more

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Cited by 25 publications
(29 citation statements)
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“…Drug sensitive strains of E. coli were shown to be potassium cation transport and homeostasis barcode deletion mutants, and this supported an ionophoric mechanism for ecteinamycin induced bacteria cell death. 30 Ecteinamycin 27 has now been isolated from both marine-and soilderived Actinomadura strains, with the latter studies (also reported in 2017) 31 securing the absolute conguration via X-ray diffraction studies.…”
Section: Marine-sourced Bacteriamentioning
confidence: 96%
“…Drug sensitive strains of E. coli were shown to be potassium cation transport and homeostasis barcode deletion mutants, and this supported an ionophoric mechanism for ecteinamycin induced bacteria cell death. 30 Ecteinamycin 27 has now been isolated from both marine-and soilderived Actinomadura strains, with the latter studies (also reported in 2017) 31 securing the absolute conguration via X-ray diffraction studies.…”
Section: Marine-sourced Bacteriamentioning
confidence: 96%
“…from Ecteinascidia turbinata led to the purification of ecteinamycin ( 22 ). It showed potent antimicrobial activity against Clostridium difficile NAP1/B1/027 [ 47 ].…”
Section: Structure and Bioactivities Of Natural Productsmentioning
confidence: 99%
“…They have also been isolated from bovine manure compost [20] and from sewage ditch [21]. Additionally, strains of this genus have been reported as the agents of actinomycete mycetoma [22], whereas others have shown the potential to produce antibiotics [10, 19, 23–27].…”
Section: Full-textmentioning
confidence: 99%