Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities
Deo Rei L. Agnila,
Taha I. Huda,
Rachel A. Eakins
et al.
Abstract:We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity determining region-3 (CDR3) amino acid (AA) sequences were assessed for chemical complementarity to cancer testis antigens, with such complementarity for FAM133A and CRISP2 associated with better survival probabilities for both datasets. These results, along wi… Show more
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