Chemical Evolution of Enzyme-Catalyzed Glycosylation
Chang-Cheng Liu,
Jinfeng Ye,
Hongzhi Cao
Abstract:A general chemical evolution strategy for site-specif ic f ucosylation was developed. The α2,6-linked sialic acid was enzymatically introduced as the protecting group to block the specific N-acetyllactosamine units f rom f ucosylation, which provides easy access for the precise synthesis of complex f ucosylated glycans.
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