Chemical Evolution and Biological Evaluation of Natural Products for Efficient Therapy of Acute Lung Injury
Chengcheng Fan,
Zeyi Zhang,
Zhencheng Lai
et al.
Abstract:Acute lung injury (ALI) is one of the most common complications in COVID‐19 and also a syndrome of acute respiratory failure with high mortality rates, but lacks effective therapeutic drugs. Natural products provide inspiration and have proven to be the most valuable source for bioactive molecule discovery. In this study, the chemical evolution of the natural product Tanshinone IIA (Tan‐IIA) to achieve a piperidine‐fused scaffold through a synthetic route of pre‐activation, multi‐component reaction, and post‐m… Show more
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