Chemical Evaluation of Betula Species in Japan. VI. Constituents of Betula schmidtii.

Fuchino, Hiroyuki; Satoh, T.; Hida, J.; Terada, M.; Tanaka, Nobutoshi

doi:10.1248/cpb.46.1051

Cited by 21 publications

(10 citation statements)

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“…In previous work, we isolated four phenolic glycosides from the wood of silver birch, Betula pendula (Hiltunen et al 2004), which is a white-barked birch tree native to Europe and Asia. Phenolics in the inner bark of B. pendula (Š mite et al 1993, 1995) and several other birch species (Pan and Lundgren 1994;Fuchino et al 1995Fuchino et al , 1996Fuchino et al , 1998a have been studied in more depth. Phenolics in the inner bark of B. pendula (Š mite et al 1993, 1995) and several other birch species (Pan and Lundgren 1994;Fuchino et al 1995Fuchino et al , 1996Fuchino et al , 1998a have been studied in more depth.…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds in silver birch (Betula pendula Roth) wood

2006

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Three new phenolic compounds (4-hydroxy-2-methoxyphenyl-6-O-syringoyl-b-D-glucopyranoside, 2-hydroxy-4-methoxyphenyl-6-O-syringoyl-b-D-glucopyranoside, and 4-hydroxymethyl-2-methoxyphenyl-6-O-syringoylb-D-glucopyranoside) and 15 known phenolic compounds (two phenyl glucoside esters, five lignans, three diarylheptanoids and five simple aldehydes or ketones) were isolated from the secondary xylem of mature Betula pendula Roth. The compounds were identified on the basis of their NMR (1D and 2D) and mass spectral data. In total, 23 phenolic extractives present in the sapwood of two winter-dormant B. pendula trees felled at different growing sites (rich in nutrients and scarce in nutrients) were quantified by GC. Their amounts were mostly low, 0.01-0.18 mg g y1 of dry wood. Total amounts of the phenolic extractives isolated were 1.2 mg g y1 of dry wood (5.6% of the total methanol-soluble extractives) in the tree felled at the site rich in nutrients, and 1.9 mg g -1 of dry wood (10% of the total methanol-soluble extractives) in the tree felled at the site scarce in nutrients.

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Section: Introductionmentioning

confidence: 99%

Phenolic compounds in silver birch (Betula pendula Roth) wood

2006

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“…Both betulin and ethanolic extracts (1 pp and 3 pp) were used to determine the reduction of edema. Betulin was found to be comparable with indometacin; however, the extracts revealed the most intense Fuchino et al (1995Fuchino et al ( , 1996aFuchino et al ( , 1996bFuchino et al ( , 1998b 3,4,5-trimethoxyphenol β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside Betula dahurica Fuchino et al (1995Fuchino et al ( , 1996bFuchino et al ( , 1998b Smite et al (1995), Fuchino et al (1996aFuchino et al ( , 1998aFuchino et al ( , 1998bFuchino et al ( , 1998c Betula dahurica Fuchino et al (1995Fuchino et al ( , 1996aFuchino et al ( , 1996bFuchino et al ( , 1998bFuchino et al ( , 1998c, Smite et al (1995), and Mshvildadze et al Betula dahurica Fuchino et al (1995Fuchino et al ( , 1998aFuchino et al ( , 1998b Betula pendula Smite et al (1995) anti-inflammatory potential probably because of the aggregation of effects of other triterpenes, also present in the extract composition, even in small concentrations (betulinic acid, lupeol etc. ).…”

Section: Antiinflammatorymentioning

confidence: 98%

“…Proliferation, activation phenotype and the number of apoptotic/necrotic cells in cell culture were analyzed by flow cytometry. Corneal transplantation was performed between Fisher and Lewis Fuchino et al (1995Fuchino et al ( , 1996bFuchino et al ( , 1998aFuchino et al ( , 1998b Betula dahurica Fuchino et al (1995Fuchino et al ( , 1996aFuchino et al ( , 1996bFuchino et al ( , 1998aFuchino et al ( , 1998bFuchino et al ( , 1998c Fuchino et al (1995Fuchino et al ( , 1996aFuchino et al ( , 1996bFuchino et al ( , 1998bFuchino et al ( , 1998c Betula ermanii Fuchino et al (1995Fuchino et al ( , 1996aFuchino et al ( , 1996bFuchino et al ( , 1998a can induce an inflammatory process to mouse ears by increasing vascular permeability, producing edema and swelling inside dermis. Indometacin was used as reference.…”

Section: Antiinflammatorymentioning

confidence: 99%

“…Specie from which isolated Reference 123 (3R)-3,5 0 -dihydroxy-4 0 -methoxy-3 0 ,4″-oxo-1,7-diphenyl-1-heptene Betula dahurica Fuchino et al (1996aFuchino et al ( , 1998aFuchino et al ( , 1998bFuchino et al ( , 1998c Cell lines used for cytotoxicity studies. Chinese hamster lung fibroblast cells Ju et al (2004) by using the membrane-permeable dye carboxyfluorescein diacetate succinimidyl ester (CFSE), respectively.…”

Section: Namementioning

confidence: 99%

“…120 ( þ )-lyoniresinol 3α-O-α-LrhamnopyranosideBetula ermaniiFuchino et al (1995Fuchino et al ( , 1996b)Betula maximowicziana 121 ( þ )-lyoniresinol 3α-O-β-DglucopyranosideBetula schmidtiiFuchino et al (1998a) 122 ( þ )-lyoniresinol 3α-O-β-D-xylopyranoside ( ¼ lyoniside)…”

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confidence: 99%

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Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review

Rastogi

Pandey

Rawat

2015

Journal of Ethnopharmacology

145

104

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Several species belonging to the genus Betula are widely used in traditional medicine. Betula platyphylla and Betula pendula have specifically been found to be potentially useful in the treatment of degenerative joint disease. There is convincing evidence in experimental animal models in support of their anti-carcinogenic effects. However, it would be worthwhile to investigate the biochemical and physiological mechanisms as well as detailed preclinical toxicity, bioavailability, pharmacokinetics and pharmacodynamics of the different biologically active extracts as well as molecules in sufficient detail. An integrated and holistic approach is required for tapping the full potentials of this important genus.

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