Chemical ecology and olfaction in arthropod vectors of diseases

Syed, Zainulabeuddin

doi:10.1016/j.cois.2015.04.011

Cited by 45 publications

(38 citation statements)

References 66 publications

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“…gambiae larval ORs [18], similar information is lacking for other species. Importantly, the mosquito olfactory subgenome exhibits significant divergence between genera [30,89]. A cross-species study of the full range of behaviorally relevant semiochemicals is crucial to understanding adult and larval chemical ecology, de-orphanizing olfactory receptors, identifying associated neurobiological functions, and inter-species differences in mosquito behavior.…”

Section: Conclusion and Prospects For Future Researchmentioning

confidence: 99%

Olfactory learning and chemical ecology of olfaction in disease vector mosquitoes: a life history perspective

Lutz

Lahondère

Vinauger

et al. 2017

Current Opinion in Insect Science

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Mosquitoes transmit many debilitating diseases including malaria, dengue and Zika. Odors mediate behaviors that directly impact disease transmission (blood-feeding) as well as life history events that contribute to mosquito survival and fitness (mating and oviposition, nectar foraging, larval foraging and predator avoidance). In addition to innate olfaction-mediated behaviors, mosquitoes rely on olfactory experience throughout their life to inform advantageous choices in many of these important behaviors. Previous reviews have addressed either the chemical ecology of mosquitoes, or olfactory-driven behaviors including host-feeding or oviposition. Adding to this literature, we use a holistic life history perspective to integrate and compare innate and learned olfactory behavior at various stages of mosquito development.

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Section: Conclusion and Prospects For Future Researchmentioning

confidence: 99%

Olfactory learning and chemical ecology of olfaction in disease vector mosquitoes: a life history perspective

Lutz

Lahondère

Vinauger

et al. 2017

Current Opinion in Insect Science

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“…Maxillary palps, the “broad spectrum odorant detectors” (Syed and Leal 2007), have only one type of olfactory sensillum that is approximately twice more abundant in females (McIver, 1971). In absence of clear evidence in mosquitoes so far, it appears that sexually dimorphic behaviors potentially result from numerical differences in sensilla, and/or the relative proportion thereof, as has been recently reviewed for other blood-feeding insects (Syed, 2015). Sexual dimorphisms in the number and size of glomeruli in the antennal lobe of the A. aegypti brain have also been identified (Ignell et al, 2005).…”

Section: Analysis Of the A Aegypti Olfactory Systemmentioning

confidence: 99%

Developmental neurogenetics of sexual dimorphism in Aedes aegypti

Duman-Scheel

Syed

2015

Front. Ecol. Evol.

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Sexual dimorphism, a poorly understood but crucial aspect of vector mosquito biology, encompasses sex-specific physical, physiological, and behavioral traits related to mosquito reproduction. The study of mosquito sexual dimorphism has largely focused on analysis of the differences between adult female and male mosquitoes, particularly with respect to sex-specific behaviors related to disease transmission. However, sexually dimorphic behaviors are the products of differential gene expression that initiates during development and therefore must also be studied during development. Recent technical advancements are facilitating functional genetic studies in the dengue vector Aedes aegypti, an emerging model for mosquito development. These methodologies, many of which could be extended to other non-model insect species, are facilitating analysis of the development of sexual dimorphism in neural tissues, particularly the olfactory system. These studies are providing insight into the neurodevelopmental genetic basis for sexual dimorphism in vector mosquitoes.

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“…Ticks, like all other blood feeding arthropods, display robust olfactory driven behaviors (Allan 2010, Mulenga 2013, Syed 2015. However, unlike insects where antennae serve as primary olfactory organs, ticks use their first pair of legs for odor detection.…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological and Behavioral Responses ofIxodes scapularisto host odors

Josek¹,

Sperrazza

Alleyne

et al. 2020

Preprint

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The black-legged tick, Ixodes scapularis (Ixodida, Ixodidae), is one of the major disease vectors in the United States and due to multiple human impact factors, such as decreasing forest size for land development and climate change, it has expanded its range and established across the United States. Throughout the life cycle, ticks locate hosts for their blood-meal and although the ecologies of this tick and their hosts have been studied in depth, the sensory physiology behind host location largely remains unexplored. Here we report establishing a robust paradigm to isolate and identify odors from the natural milieu for I. scapularis. We performed single sensillum recordings (SSR) from the olfactory sensilla on the tick tarsi, and used the SSR system as biological detector to isolate natural compounds that elicited biological activity. The SSR setup was further tested in tandem with gas chromatography (GC) wherein the ticks’ olfactory sensillum activity served as a biological detector. The GC-SSR recordings from the wall pore sensilla in the Haller’s organ, and further identification of the biologically active deer glad constituents by GC-mass spectrometry (GC-MS) revealed methyl substituted phenols as strong chemostimuli, as compared to ethyl or propyl substitutions. Strongest electrophysiological activity was elicited by meta-cresol followed by para-cresol. Ethyl- and propylphenols with any of the three, ortho, meta or para substitutions, did not induce any neurophysiological activity. Finally, a behavioral analysis in a dual-choice olfactometer of all these phenols at three different doses revealed no significant behavioral response, except for p-cresol at −3 dilution Overall, this study contributes to our understanding of I. scapularis tick’s neurophysiology and provides a robust platform to isolate and identify natural attractants and repellents.

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Chemical ecology and olfaction in arthropod vectors of diseases

Cited by 45 publications

References 66 publications

Olfactory learning and chemical ecology of olfaction in disease vector mosquitoes: a life history perspective

Olfactory learning and chemical ecology of olfaction in disease vector mosquitoes: a life history perspective

Developmental neurogenetics of sexual dimorphism in Aedes aegypti

Neurophysiological and Behavioral Responses ofIxodes scapularisto host odors

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