Chemical Determination of the Potency of Thyroid Preparations

Moody, Joseph E.; Hohmann, John R.; Kaplan, Gilbert B.

doi:10.1002/jps.2600570419

Cited by 12 publications

(2 citation statements)

References 14 publications

(4 reference statements)

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“…It plays vital roles in the normal growth and development of the body and in the maturation of sexual organs. To date, various techniques such as radioimmunoassay (RIA) [21], enzyme immunoassay [22], thin-layer chromatography [23] and gas chromatography mass spectroscopy (GC-MS) [24] have been widely used to determine thyroxine in the blood serum and urine samples. On the basis of the reduction of thyroxine, electrochemical techniques such as differential pulse polarography (DPV) [25], DPV with the use of a silver-disc rotating electrode [26], and cathodic stripping square-wave voltammetry [27] were also applied to detect thyroxine.…”

Section: Introductionmentioning

confidence: 99%

The fabrication of a carbon nanotube film on a glassy carbon electrode and its application to determining thyroxine

Fei

et al. 2003

Nanotechnology

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An easy and convenient technique to fabricate a carbon nanotube (CNT) film on a glassy carbon electrode (GCE) is described. In the presence of a hydrophobic surfactant, insoluble multi-walled carbon nanotubes (MWNTs) were dispersed into water to give a homogeneous and stable suspension. After solvent evaporation, a stable and uniform CNT film was achieved on the GCE surface. The MWNT film was characterized by scanning electron microscopy and transmission electron microscopy images. The electrochemical behaviour of thyroxine at the MWNT film-coated GCE was investigated. It was found that this novel CNT film can remarkably enhance the sensitivity of determination of thyroxine. Consequently, a novel electrochemical method was developed for the determination of thyroxine with simplicity and high sensitivity. The analysis method is demonstrated by using human blood serums.

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Section: Introductionmentioning

confidence: 99%

The fabrication of a carbon nanotube film on a glassy carbon electrode and its application to determining thyroxine

Fei

et al. 2003

Nanotechnology

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“…Dry natural protein containing thyroid hormones yielded to a UV method using I2. 16 However, this useful but nonspecific and relatively insensitive method could not be used for single tablet assay and was tedious. A new method, depending on the conversion of all iodine atoms to I3, was developed for the analyses of sodium levothyroxine (T4) and sodium liothyronine (T3).17…”

mentioning

confidence: 99%

Chemical Data: An Essential Tool in the Regulation of Drugs

Benson¹,

Wright²

1979

J. Chem. Inf. Comput. Sci.

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How the Bureau of Drugs laboratories and offices obtain chemical data from the scientific literature, from user complaints and product defect reporting systems, from the drug manufacturers, from analyses of drug samples collected from the market, and from analytical research are described. The chemical data thus educed have been used successfully in developing new analytical methods, in establishing better specifications of drug quality, in removing adulterated drugs from the marketplace, in successfully prosecuting purveyors of substandard drugs, and in general assuring that consumers are provided with safe and effective drugs of high quality.

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Determination of Liothyronine and Thyroxine in Dried Thyroid by GLC

Bilous

Windheuser

1973

Journal of Pharmaceutical Sciences

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Chemical Determination of the Potency of Thyroid Preparations

Cited by 12 publications

References 14 publications

The fabrication of a carbon nanotube film on a glassy carbon electrode and its application to determining thyroxine

The fabrication of a carbon nanotube film on a glassy carbon electrode and its application to determining thyroxine

Chemical Data: An Essential Tool in the Regulation of Drugs

Determination of Liothyronine and Thyroxine in Dried Thyroid by GLC

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