Chemical cross-linking of chitosan/polyvinyl alcohol electrospun nanofibers

Abstract

Electrospun nanofibrous scaffolds have great potential for many biomedical applications. In the present study, we fabricated and characterized chitosan/polyvinyl alcohol (Chi/PVA) nanofibrous scaffolds through electrospinning. Cross-linking was performed using chemically with 5 % glutaraldehyde vapor. The morphology and chemical banding of the electrospun nanofibers before and after cross-linking were evaluated using scanning electron microscopy (SEM) and Attenuated Total ReflectanceFourier Transform InfraRed (ATR-FTIR) spectroscopy. SEM micrographs and FTIR spectra showed that the cross-linking process was accomplished successfully. With the biocompatibility and non-toxicity of chitosan and PVA, it is expected that this electrospun nanofibrous scaffold could be an excellent candidate for biomedical applications. Keywords: electrospinning, chitosan, polyvinyl alcohol, cross-linking Mre`e iz elektro spredenih nanovlaken imajo velik potencial za uporabo v biomedicini. V {tudiji smo izdelali in karakterizirali nanovlaknasto mre`o, izdelano z elektro predenjem nanovlaken iz hitosan/polivinil alkohola (Chi/PVA). Zamre`enje je bilo izdelano s pomo~jo kemijske metode s 5 % glutaraldehidne pare. Morfologija in kemijsko povezovanje elektro predenih nanovlaken, pred in po zamre`enju, sta bila ocenjena z uporabo vrsti~nega elektronskega mikroskopa (SEM) in z metodo z oslabljenim odbojem infrarde~e spektroskopije s Fourierjevo transformacijo (ATR-FTIR). SEM-posnetki in FTIR-spekter sta pokazala, da je bil postopek zamre`enja uspe{no dose`en. Glede na biokompatibilnost in netoksi~nost hitosana in PVA se pri~akuje, da bodo mre`e iz elektro spredenih nanovlaken odli~en element za uporabo v biomedicini.

Fabrication of chitosan/polyvinyl alcohol/amine modified carbon nanotube composite films for rapid chromate removal

“…Accordingly, the spectrum of CS/PVA included all characteristic peaks assigned to CS and PVA structures 29,38 . The band observed at 1234 cm −1 which is accepted as an indication of intermolecular hydrogen bonding between CO of CS and OH of PVA was also present for a‐MWCNT added composites 39 . However, with the inclusion of a‐MWCNT to the structure, a slight shifting was observed in the peak around 3,275 cm −1 to 3,250 cm −1 corresponding to NH and OH stretching vibrations of CS and PVA, respectively.…”

Formulation and Evaluation of in Vitro Transdermal Patch Diclofenac Sodium Using Chitosan Polymer and Polyvinyl Alcohol Cross-Linked Tripolyphosphate Sodium

“…Ch -PVA-TPP solution containing diclofenac sodium is disonified for 1 min to produce a good particle disperse [32]. One drop of the solution is dispersed into carbon-coated copper gird which is then dried at room temperature for SEM photography analysis.…”

“…Ch is widely used because it has the characteristics of biocompatibility, non-toxic, and antimicrobial [13]. Ch and alcohol PVA that are hydrophilic will increase patch permeability and drug diffusion [12,32]. Ch with alcohol PVA produces cross-linking hydrogels with good swelling activity.…”

Carboxymethyl Cellulose (CMC) Based Electrospun Composite Nanofiber Mats for Food Packaging

“…Polylactic acid (PLA), chitosan [ 7 , 8 ], cellulose [ 2 , 3 , 9 ], zein [ 9 ], silk, and other polymers are some of the most used polymers in the field of biomedical engineering, environmental engineering, food packaging [ 10 ], tissue engineering, and other applications. Natural polymers are usually modified or blended with synthetic polymers to increase application areas due to higher productivity and smoother processing of synthetic polymers [ 1 , 7 , 8 , 11 , 12 , 13 , 14 , 15 ]. Nanofibers fabricated by either production method have multiple application areas, especially in life science (tissue engineering, biomedical engineering, including implants, wound dressing, drug delivery, etc.…”

“…CMC and PVA together possess the strong interaction due to the hydrogen bonding. Both polymers are known for their solubility in water, which leads them towards the homogeneous solution [ 8 , 12 , 43 ]. PVP is famous due to its hydrophilicity.…”