Chemical control of breathing in identical twin athletes

Ag, Leitch

doi:10.1080/03014467600001711

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…The HVR was decreased to a similar extent in runners and their relatives compared with the nonathletic controls. Second, identical twin studies suggest that when the effect of physical activity is removed, genetic factors predominate in determining HVR (14,15). This is further supported by recent work that has implicated ancestry as a main explanation for the blunted response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives (1).…”

Section: Discussionmentioning

confidence: 72%

Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity

Sheel¹,

Koehle²,

Guenette³

et al. 2006

Journal of Applied Physiology

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Ventilatory responsiveness to hypoxia (HVR) has been reported to be different between highly trained endurance athletes and healthy sedentary controls. However, a linkage between aerobic capacity and HVR has not been a universal finding. The purpose of this study was to examine the relationship between HVR and maximal oxygen consumption (VO2 max) in healthy men with a wide range of aerobic capacities. Subjects performed a HVR test followed by an incremental cycle test to exhaustion. Participants were classified according to their maximal aerobic capacity. Those with a VO2 max of >or=60 ml x kg(-1) x min(-1) were considered highly trained (n = 13); those with a VO2 max of 50-60 ml x kg(-1) x min(-1) were considered moderately-trained (n = 18); and those with a VO2 max of <50 ml x kg(-1) x min(-1) were considered untrained (n = 24). No statistical differences were detected between the three groups for HVR (P > 0.05), and the HVR values were variable within each group (range: untrained = 0.28-1.61, moderately trained = 0.23-2.39, and highly trained = 0.08-1.73 l x min.%arterial O2 saturation(-1)). The relationship between HVR and VO2 max was not statistically significant (r = -0.1723; P > 0.05). HVR was also unrelated to maximal minute ventilation and ventilatory equivalents for O2 and CO2. We found that a spectrum of hypoxic ventilatory control is present in well-trained endurance athletes and moderately and untrained men. We interpret these observations to mean that other factors are more important in determining hypoxic ventilatory control than physical conditioning per se.

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Section: Discussionmentioning

confidence: 72%

Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity

Sheel¹,

Koehle²,

Guenette³

et al. 2006

Journal of Applied Physiology

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“…A further source or variability is that most of the previous work investigated the hypoxic ventilatory response at rest, rather than during exercise, which is thought to augment the response (Weil et al., 1972). Genetic differences have also been shown to impact both hypoxic and hypercapnic chemoresponsiveness (Weil, 2003), with the hypoxic ventilatory response being similar in twins when exercise training was accounted for (Leitch, 1976).…”

Section: Discussionmentioning

confidence: 99%

Peripheral chemoresponsiveness during exercise in male athletes with exercise‐induced arterial hypoxaemia

Granger

Cooper

Hopkins

et al. 2020

Experimental Physiology

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New Findings What is the central question of this study?Do highly trained male endurance athletes who develop exercise‐induced arterial hypoxaemia (EIAH) demonstrate reduced peripheral chemoresponsiveness during exercise? What is the main finding and its importance?Those with the lowest arterial saturation during exercise have a smaller ventilatory response to hypercapnia during exercise. There was no significant relationship between the hyperoxic ventilatory response and EIAH. The findings suggest that peripheral chemoresponsiveness to hypercapnia during exercise could play a role in the development of EIAH. The findings improve our understanding of the mechanisms that contribute to EIAH. Abstract Exercise‐induced arterial hypoxaemia (EIAH) is characterized by a decrease in arterial oxygen tension and/or saturation during whole‐body exercise, which may in part result from inadequate alveolar ventilation. However, the role of peripheral chemoresponsiveness in the development of EIAH is not well established. We hypothesized that those with the most severe EIAH would have an attenuated ventilatory response to hyperoxia and hypercapnia during exercise. To evaluate this, on separate days, we measured ventilatory sensitivity to hyperoxia and separately hypercapnia at rest and during three different exercise intensities (25, 50% of V̇O2normalmax and ventilatory threshold (∼67% of V̇O2normalmax)) in 12 males cyclists (V̇O2normalmax = 66.6 ± 4.7 ml kg−1 min−1). Subjects were divided into two groups based on their end‐exercise arterial oxygen saturation (ear oximetry, SnormalpO2): a normal oxyhaemoglobin saturation group (NOS, SnormalpO2 = 93.4 ± 0.4%, n = 5) and a low oxyhaemoglobin saturation group (LOS, SnormalpO2 = 89.9 ± 0.9%, n = 7). There was no difference in V̇O2normalmax (66.4 ± 2.9 vs. 66.8 ± 6.0 ml kg−1 min−1, respectively, P = 0.9), peak ventilation during maximal exercise (182 ± 15 vs. 197 ± 32 l min−1, respectively, P = 0.36) or ventilatory response to hyperoxia (P = 0.98) at any exercise intensity between NOS and LOS groups. However, those in the LOS group had a significantly lower ventilatory response to hypercapnia (P = 0.004, (η2 = 0.18). There was also a significant relationship between the mean hypercapnic response and end‐exercise SnormalpO2 (r = 0.75, P = 0.009) but not between the mean hyperoxic response and end‐exercise SnormalpO2 (r = 0.21, P = 0.51). A blunted hypercapnic ventilatory response may contribute to EIAH in highly trained men due to a failure to increase ventilation sufficiently to offset exercise‐induced gas exchange impairments.

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Hereditary aspects of respiratory control in health and disease in humans

Weil

Genetic Basis for Respiratory Control Disorders

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Chemical control of breathing in identical twin athletes

Cited by 6 publications

References 15 publications

Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity

Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity

Peripheral chemoresponsiveness during exercise in male athletes with exercise‐induced arterial hypoxaemia

Hereditary aspects of respiratory control in health and disease in humans

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