Chemical constituents of Vernonanthura crassa (Vell.) H. Rob. (Asteraceae)

Peixoto, Juliana Luna Bilheiro; Areas, Drielli Rhiane P. Colhado; Baldoqui, Débora Cristina; Carmo, Marta Regina Barrotto do; Costa, Willian Ferreira da; Sarragiotto, María Helena

doi:10.1016/j.bse.2018.05.002

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…The dereplication study was supported by an in-house database from our previous work on Asteraceae species [6,12] and allowed the putative identification of six hirsutinolide-type sesquiterpene lactones (14)(15)(16)(17)(18)(19) and two cadinanolides (20)(21). The isolated (1, 3, 5 and 6) and putatively-identified (14-19) sesquiterpene lactones showed the same fragmentation pattern (Table 2) described for hirsutinolide-type SLs (Figure S13).…”

Section: Dereplication Of Sesquiterpene Lactones and Flavonoids Using...mentioning

confidence: 53%

“…The use of mass spectrometry-based molecular networking as a dereplication strategy allowed the identification of six hirsutinolides (14)(15)(16)(17)(18)(19), two cadinanolides (20-21) and three flavonoids (22)(23)(24). Compounds 14-16 and 22-24 were previously identified in Lessingianthus genus while compounds 17-21 are being described for the first time in L. rubricaulis and in the genus.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies on Asteraceae species, including species from Lessingianthus genus, also resulted in the isolation of hirsutinolide-and germacranolide-type sesquiterpene lactones, some of them exhibiting cytotoxic activities. [6,12,17,18] Therefore, to continue our phytochemical investigation of Lessingianthus species, in this work we undertook the phytochemical study of L. rubricaulis. Previous phytochemical investigation of Lessingianthus rubricaulis (Less.)…”

Section: Introductionmentioning

confidence: 99%

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Hirsutinolide‐ and Cadinanolide‐type Sesquiterpene Lactones from Lessingianthus rubricaulis (Vernonieae, Asteraceae)

Colhado Arêas,

Porto,

Cabral

et al. 2024

Chemistry & Biodiversity

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Sesquiterpene lactones are an important class of secondary metabolites frequently isolated from Lessingianthus genus that present a variety of biological properties, such as antimalarial, anti‐inflammatory, antileishmanial, antitrypanosomal and anticancer. The limited phytochemical studies and the importance of this class of compounds isolated from Lessingianthus led us to study this genus. In this work, we focused on the phytochemical investigation and dereplication based on UHPLC‐HRMS/MS and molecular networking of L. rubricaulis. Chemical investigation resulted in the isolation of several hirsutinolide‐type sesquiterpene lactones including a new hirsutinolide derivative, 8,10α‐hydroxy‐1,13‐bis‐O‐methylhirsutinolide, besides a cadinanolide and flavonoids. The dereplication study resulted in the identification of three known flavonoids, six known hirsutinolides and two known cadinanolides. Moreover, a fragmentation pathway for cadinanolide‐type sesquiterpene lactones was proposed. These results contribute to chemotaxonomic studies and demonstrates the potential of Lessingianthus genus.

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Section: Dereplication Of Sesquiterpene Lactones and Flavonoids Using...mentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hirsutinolide‐ and Cadinanolide‐type Sesquiterpene Lactones from Lessingianthus rubricaulis (Vernonieae, Asteraceae)

Colhado Arêas,

Porto,

Cabral

et al. 2024

Chemistry & Biodiversity

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Chemical constituents and dereplication study of Lessingianthus brevifolius (Less.) H.Rob. (Asteraceae) by UHPLC-HRMS and molecular networking

Areas

Cabral

Ramos

et al. 2020

Natural Product Research

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Essential oils from leaves of Vernonanthura montevidensis (Spreng.) H. Rob.: chemical profile and antimollicute potential

Rebelo

Tizziani

Begnini

et al. 2020

Natural Product Research

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Aiming to valorise the Atlantic Rainforest biodiversity in Santa Catarina, the chemical characterization of the essential oils (EOs) from leaves of Vernonanthura montevidensis (Spreng.) H. Rob. is described for the first time. Fresh leaves collected in the year 2014 and 2015, were submitted to hydrodistillation to give pale blue EOs in yields of 0.21 and 0.19%, respectively. The EOs were characterized by GC-MS and GC-FID quantitative method. The monoterpene β-pinene was the major constituent in both samples reaching a maximum of 26.3%. Besides β-pinene, the monoterpene α-pinene and the sesquiterpene β-caryophyllene, were among the major constituents in both samples. By means of extracted ion chromatogram procedure, it was possible to detect chamazulene, which was associated to the pale blue colour of the essential oils. In the in vitro antimollicute assays, the essential oil was moderately active against Mycoplasma genitalium and M. pneumoniae with MIC values of 250 µg mL -1 .

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Chemical constituents of Vernonanthura crassa (Vell.) H. Rob. (Asteraceae)

Cited by 3 publications

References 28 publications

Hirsutinolide‐ and Cadinanolide‐type Sesquiterpene Lactones from Lessingianthus rubricaulis (Vernonieae, Asteraceae)

Hirsutinolide‐ and Cadinanolide‐type Sesquiterpene Lactones from Lessingianthus rubricaulis (Vernonieae, Asteraceae)

Chemical constituents and dereplication study of Lessingianthus brevifolius (Less.) H.Rob. (Asteraceae) by UHPLC-HRMS and molecular networking

Essential oils from leaves of Vernonanthura montevidensis (Spreng.) H. Rob.: chemical profile and antimollicute potential

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