Chemical constituents of the roots of Rheum officinale

Gao, Liangliang; Xu, Xudong; Yang, Junshan

doi:10.1007/s10600-013-0689-7

Cited by 26 publications

(13 citation statements)

References 5 publications

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“…Similarly carbon atoms directly linked with oxygen displayed signals at 161.4, 103.4 and 160.2. The spectroscopic data was also matched with the reported data in literature and compound ( 9 ) was identified as 3,4′,5,7-tetrahydroxyflavone commonly known as kaempferol 27 .…”

Section: Resultssupporting

confidence: 75%

Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina

Javed

Mahmood

Khan

et al. 2021

Sci Rep

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Antifungal activity of Monothecabuxifolia methanolic extract and its various fractions were assessed against Macrophominaphaseolina, a soil-borne fungal pathogen of more than 500 vegetal species as well as rare and emerging opportunistic human pathogen. Different concentrations of methanolic extract (3.125 to 200 mg mL−1) inhibited fungal biomass by 39–45%. Isolated n-hexane, chloroform and ethyl acetate fractions suppressed fungal biomass by 32–52%, 29–50% and 29–35%, respectively. Triterpenes lupeol and lupeol acetate (1, 2) were isolated from n-hexane while betulin, β-sitosterol, β-amyrin, oleanolic acid (3–6) were isolated from chloroform fraction. Vanillic acid, protocatechuic acid, kaempferol and quercetin (7–10) were isolated from the ethyl acetate fraction and identified using various spectroscopic techniques namely mass spectroscopy and NMR. Antifungal activity of different concentrations (0.0312 to 2 mg mL−1) of the isolated compounds was evaluated and compared with the activity of a broad spectrum fungicide mancozeb. Different concentrations of mencozeb reduced fungal biomass by 83–85%. Among the isolated compounds lupeol acetate (2) was found the highest antifungal against M.phaseolina followed by betulin (3), vanillic acid (7), protocatechuic acid (8), β-amyrin (5) and oleanolic acid (6) resulting in 79–81%, 77–79%, 74–79%, 67–72%, 68–71% and 68–71%, respectively. Rest of the compounds also showed considerable antifungal activity and reduced M.phaseolina biomass by 41–64%.

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Section: Resultssupporting

confidence: 75%

Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina

Javed

Mahmood

Khan

et al. 2021

Sci Rep

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“…growing in Egypt [36] and the roots of Rheum officinale, respectively [37]. Their structures were identified by 1 H and 13 C NMR data, which were consistent with those in references [38,39].…”

Section: Structure Elucidationsupporting

confidence: 85%

Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine

et al. 2015

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“…At present, the research on Rheum plants is mainly focused on the investigation of their resource distribution [1,6], chemical composition [7][8][9][10][11], pharmacological effects [12][13][14][15], and side effects [16]. Because Rheum comprises highly phenotypically plastic Chinese herbal medicine species, there are significant differences in the quality and efficacy of different species or varieties of the same origin [2].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Comparative Analysis of Two Rheum Complete Chloroplast Genomes

Zhao

et al. 2020

BioMed Research International

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Rheum species present a significant economic value. Traditional Chinese medicine rhubarb is an important medicinal material in China. It has a long history of use, with a record of use as early as two thousand years ago. Here, we determined the complete chloroplast genome sequences of Rheum nobile and Rheum acuminatum and comprehensively compared them to two other available Rheum cp genomes at the genome scale. The results revealed cp genomes ranging in size from 159,051 to 161,707 bp with a similar typical quadripartite and circular structure. The genome organization, gene numbers, gene order, and GC contents of these four Rheum cp genomes were similar to those of many angiosperm cp genomes. Repeats and microsatellites were detected in the R. nobile and R. acuminatum cp genomes. The Mauve alignment revealed that there were no rearrangements in the cp genomes of the four Rheum species. Thirteen mutational hotspots for genome divergence were identified, which could be utilized as potential markers for phylogenetic studies and the identification of Rheum species. The phylogenetic relationships of the four species showed that the members of Rheum cluster into a single clade, indicating their close relationships. Our study provides valuable information for the taxonomic, phylogenetic, and evolutionary analysis of Rheum.

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Chemical constituents of the roots of Rheum officinale

Cited by 26 publications

References 5 publications

Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina

Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina

Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine

Characterization and Comparative Analysis of Two Rheum Complete Chloroplast Genomes

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