Chemical Constituents of the Roots of Michelia champaca

Lin, Chien‐Liang; Kao, C. L.; Li, W. J.; Li, H. T.; Chen, C. Y.

doi:10.1007/s10600-018-2332-0

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…27 In 2018, the previously reported N-methylcorydaldine (6) together with two more isoquinoline alkaloids 7-methoxy-1,2,3,4-tetrahydroisoquinolin-1-one (8) and thalifoline (9) were isolated from Michelia champaca. 26 Other studies in same year described the isolation as well as hepatoprotective activities of the latter compound (9), N-methylisosalsoline (5), corydaldine (10), oxohydrastinine (11), 6,7-methylenedioxy-1(2H)-isoquinolinone (12), and oxyhydrastinine (13) from Corydalis tomentella, Corydalis hendersonii, and Plumula nelumbinis. [28][29][30] 6,7-Dihydroxy-1-methyl-3,4-dihydroisoquinolone (14), (S)-(−)-salsolinol (15), 6,7-dihydroxy-3,4-dihydroisoquinolone (16), and (R)-(+)-1-isobutyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (17), were isolated from the medicinal plant Portulaca oleracea.…”

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

“…53 C. hendersonii and C. japonica were found to contain tetrahydropalmatine (192) and 8-hydroxy-7,8-dihydrocoptisine (1 93), respectively. 26,60 Cavidine (194) was isolated from Corydalis impatiens. 75 In 2016, (−)-stylopine (195), (−)-sinactine (196), and (−)-cheilanthifoline (197) were isolated from aerial parts of F. officinalis.…”

Section: Protoberberine Isoquinoline Alkaloidsmentioning

confidence: 99%

“…In 2018, the previously reported N ‐methylcorydaldine ( 6 ) together with two more isoquinoline alkaloids 7‐methoxy‐1,2,3,4‐tetrahydroisoquinolin‐1‐one ( 8 ) and thalifoline ( 9 ) were isolated from Michelia champaca 26 . Other studies in same year described the isolation as well as hepatoprotective activities of the latter compound ( 9 ), N ‐methylisosalsoline ( 5 ), corydaldine ( 10 ), oxohydrastinine ( 11 ), 6,7‐methylenedioxy‐1(2 H )‐isoquinolinone ( 12 ), and oxyhydrastinine ( 13 ) from Corydalis tomentella, Corydalis hendersonii , and Plumula nelumbinis 28–30 …”

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

“…In 2016, the new isoquinoline alkaloid fumaranine ( 72 ) together with seven other alkaloids, (−)‐fumaricine ( 73 ), (+)‐dihydrofumariline ( 74 ), (−)‐fumaritine ( 75 ), (−)‐ O ‐methylfumarophycine ( 76 ), (−)‐fumarophycine ( 77 ), (+)‐fumariline ( 78 ), (+)‐parfumidine ( 79 ), and (+)‐parfumine ( 80 ) were found from the aerial parts of F. officinalis 24 . Also, four new spirobenzylisoquinoline N ‐oxide alkaloids hendersines C‐F ( 81 – 84 ) were identified from C. hendersonii 26 (Figure 4).…”

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

“…A new compound 13‐carboxaldehyde‐8‐oxocoptisine ( 191 ) together with 177 were isolated from the traditional Chinese preparation Coptidis Rhizoma ‐ Euodiae Fructus couple, used to treat gastrointestinal disorders 53 . C. hendersonii and C. japonica were found to contain tetrahydropalmatine ( 192 ) and 8‐hydroxy‐7,8‐dihydrocoptisine ( 1 93 ), respectively 26,60 . Cavidine ( 194 ) was isolated from Corydalis impatiens 75 .…”

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

133

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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