Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities

So, Hae Min; Yu, Jae Sik; Khan, Zarha; Subedi, Lalita; Ko, Yoon‐Joo; Lee, Il Kyun; Park, Woo Sung; Chung, Sang J.; Ahn, Mi‐Jeong; Kim, Sun Yeou; Kim, Ki‐Hyun

doi:10.1016/j.bioorg.2019.103145

Cited by 32 publications

(17 citation statements)

References 58 publications

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“…Recent scientific studies showed that the administration of Epimedium flavonoids improved learning and memory ability through the suppression of microglia and astrocyte activation, resulting in a decrease in the production of IL-1β and TNF-α in the hippocampus of an Alzheimer’s disease mouse model [ 16 ]. Moreover, cumulative studies revealed that megastigmane and its glucoside and glycoside derivatives had a potential to inhibit NO production in LPS-stimulated BV2 cells [ 17 , 18 , 19 ]. ICSB is a naturally occurring megastigmane glucoside found in various plants, including Allium victorialis var.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades

et al. 2020

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: Prolonged inflammatory responses can lead to the development of several chronic diseases, such as autoimmune disorders and the development of natural therapeutic agents is required. A murine model was used to assess the anti-inflammatory effects of the megastigmane glucoside, icariside B2 (ICSB), and the assessment was carried out in vitro, and in vivo. The in vitro anti-inflammatory effects of ICSB were tested using LPS-stimulated BV2 cells, and the protein expression levels of inflammatory genes and cytokines were assessed. Mice were subcutaneously injected with 1% carrageenan (CA) to induce acute phase inflammation in the paw. Inflammation was assessed by measuring paw volumes hourly; subsequently, the mice were euthanized and the right hind paw skin was expunged and processed for reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analyses. ICSB inhibits LPS-stimulated nitric oxide (NO) and prostaglandin E2 (PGE2) generation by reducing the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). ICSB also inhibits the COX-2 enzyme with an IC50 value of 7.80±0.26 µM. Molecular docking analysis revealed that ICSB had a strong binding affinity with both murine and human COX-2 proteins with binding energies of −8 kcal/mol and −7.4 kcal/mol, respectively. ICSB also reduces the manifestation of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, at their transcriptional and translational level. ICSB hinders inhibitory protein κBα (IκBα) phosphorylation, thereby terminating the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) nuclear translocation. ICSB also represses the mitogen-activated protein kinases (MAPKs) signaling pathways. ICSB (50 mg/kg) showed an anti-edema effect in CA-induced mice and suppressed the CA-induced increases in iNOS and COX-2 protein levels. ICSB attenuated inflammatory responses by downregulating NF-κB expression through interference with extracellular signal-regulated kinase (ERK) and p38 phosphorylation, and by modulating the expression levels of iNOS, COX-2, TNF-α, IL-1β, and IL-6.

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Section: Discussionmentioning

confidence: 99%

Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades

et al. 2020

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“…To acquire the optimal conformation of 1a/1b, computational DFT calculations were performed [23][24][25][26][27]. Detailed information is provided in the section of computational analysis in Supplementary Materials.…”

Section: Computational Analysismentioning

confidence: 99%

Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius

Baek

Lee

et al. 2020

Plants

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Carthamus tinctorius L. (Compositae; safflower or Hong Hua) has been used in Korean traditional medicine for maintaining the homeostasis of body circulation. Phytochemical investigation was performed on the florets of C. tinctorius by liquid chromatography–mass spectrometry (LC/MS), which afforded two dihydrophaseic acid glucosides (1 and 2). Isolated compounds were structurally confirmed using a combination of spectroscopic methods including 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionization mass spectroscopy. Their absolute configurations were established by quantum chemical electronic circular dichroism calculations and enzymatic hydrolysis. The anti-adipogenesis activity of the isolated compounds was evaluated using 3T3-L1 preadipocytes. Treatment with the dihydrophaseic acid glucoside (1) during adipocyte differentiation prevented the accumulation of lipid droplets and reduced the expression of adipogenic genes, Fabp4 and Adipsin. However, compound 2 did not affect adipogenesis. Our study yielded a dihydrophaseic acid glucoside derived from C. tinctorius, which has potential advantages for treating obesity.

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“…brevipetiolata, (roots) [36], Metrodorea nigra (fresh fruits) [37], Leea indica (Vitaceae) (leaves) [38], Cytathostemma argenteum (leaves and twings) [39], Ulmus davidiana var. japonica (Ulmaceae) (root bark) [40], Glycyrrhiza iconica (roots) [41], Artocarpus altillis [42], Balanophora involucrata [43], Radula variabilis [44], Uvaria angolensis (roots) [45], Lithocarpus pachyphyllus (Fagaceae) [46], Lithocarpus polystachyus (called Sweet Tea) [47], Piper aduncum [48], Desmodium caudatum [49], Sinningia hatschbachii [50], and Colvillea racemosa [51].…”

Section: Dihydrochalcones From Natural Sourcesmentioning

confidence: 99%

Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review

2019

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Dihydrochalcones are a class of secondary metabolites, for which demand in biological and pharmacological applications is still growing. They posses several health-endorsing properties and, therefore, are promising candidates for further research and development. However, low content of dihydrochalcones in plants along with their low solubility and bioavailability restrict the development of these compounds as clinical therapeutics. Therefore, chemomicrobial and enzymatic modifications are required to expand their application. This review aims at analyzing and summarizing the methods of obtaining dihydrochalcones and of presenting their pharmacological actions that have been described in the literature to support potential future development of this group of compounds as novel therapeutic drugs. We have also performed an evaluation of the available literature on beneficial effects of dihydrochalcones with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, antioxidant, anti-inflammatory, antibacterial, antiviral, and immunomodulatory ones. In addition, we provide useful information on their properties, sources, and usefulness in medicinal chemistry.

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Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities

Cited by 32 publications

References 58 publications

Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades

Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades

Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius

Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review

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