Chemical Constituents of the Fungus Veronaea sp.

Zhou, Liang; Zheng, Xi; Wan, Chunping; Yu, Zefen; Zhang, Ke‐Qin; Li, Guohong

doi:10.1007/s10600-015-1259-y

Cited by 6 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, cochlioquinone (2) and anhydrocochlioquinone A (4) showed cytotoxicities against mammalian cells, RAW 264.7 cells, in all concentrations with IC 50 values of <11.73 and <12.14 µM, respectively. The previous report showed that anhydrocochlioquinone A (4) displayed weak cytotoxicity against lung cancer (A549) cell line with the inhibition ratio of 41% at 30 µg/mL [40]. In this study, anhydrocochlioquinone A (4) showed the cytotoxicity against lung cancer (A549) cell line with the IC 50 value of <12.14 µM, which agrees with the previous report.…”

Section: Cytotoxicity Against the Three Cancer Cell Lines Including Lung Cancer A549 Colorectalsupporting

confidence: 92%

“…[ 36 ], and Veronaea sp. (Incertae sedis) [ 40 ]. Terpeatacin ( 6 ) is a bicyclo sesterterpene containing a 5-membered ring fusing with a 15-membered ring and was isolated for the first time in Curvularia sp.…”

Section: Resultsmentioning

confidence: 99%

“…The previous report showed that anhydrocochlioquinone A ( 4 ) displayed weak cytotoxicity against lung cancer (A549) cell line with the inhibition ratio of 41% at 30 µg/mL [ 40 ]. In this study, anhydrocochlioquinone A ( 4 ) showed the cytotoxicity against lung cancer (A549) cell line with the IC 50 value of <12.14 µM, which agrees with the previous report.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Suthiphasilp

Raksat

Maneerat

et al. 2021

JoF

View full text Add to dashboard Cite

Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC50 values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 µM.

show abstract

Section: Cytotoxicity Against the Three Cancer Cell Lines Including Lung Cancer A549 Colorectalsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Suthiphasilp

Raksat

Maneerat

et al. 2021

JoF

View full text Add to dashboard Cite

show abstract

“…[27], Drechslera dematioidea [15], and Veronaea sp. [35], most of which are Dothideomycetes. Significantly, this is the first report pertaining to sativene-type sesquiterpenoids from B. sorokiniana in 25 years, since the first and only literature account was published in 1994 [2].…”

Section: Resultsmentioning

confidence: 99%

Bipolenins K–N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Phan¹,

Li²,

Kessler³

et al. 2019

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

Chemical investigation of the barley and wheat fungal pathogen Bipolaris sorokiniana BRIP10943 yielded four new sativene-type sesquiterpenoid natural products, bipolenins K–N (1–4), together with seven related known analogues (5–11), and a sesterterpenoid (12). Their structures were determined by detailed analysis of spectroscopic data, supported by TDDFT calculations and comparison with previously reported analogues. These compounds were evaluated for their phytotoxic activity against wheat seedlings and wheat seed germination. The putative biosynthetic relationships between the isolated sesquiterpenoids were also explored.

show abstract

“…Cochlioquinone has already been reported to cause toxic reactions in various cancer cells [ 60 , 61 ]. In particular, Zhou et al (2015) [ 62 ] identified that cochlioquinone caused cytotoxicity in the A549 cell line and SK-OA-3 cell line, which are cells that mainly cause cancer in humans. We succeeded in extracting cq-9 from rice for the first time and inoculated into the sepsis-inducing model mice.…”

Section: Discussionmentioning

confidence: 99%

The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo

et al. 2021

View full text Add to dashboard Cite

Unpredictable climate change might cause serious lack of food in the world. Therefore, in the present world, it is urgent to prepare countermeasures to solve problems in terms of human survival. In this research, quantitative trait loci (QTLs) were analyzed when rice attacked by white backed planthopper (WBPH) were analyzed using 120 Cheongcheong/Nagdong double haploid lines. Moreover, from the detected QTLs, WBPH resistance-related genes were screened in large candidate genes. Among them, OsCM, a major gene in the synthesis of Cochlioquinone-9 (cq-9), was screened. OsCM has high homology with the sequence of chorismate mutase, and exists in various functional and structural forms in plants that produce aromatic amino acids. It also induces resistance to biotic stress through the synthesis of secondary metabolites in plants. The WBPH resistance was improved in rice overexpressed through map-based cloning of the WBPH resistance-related gene OsCM, which was finally detected by QTL mapping. In addition, cq-9 increased the survival rate of caecal ligation puncture (CLP)-surgery mice by 60%. Moreover, the aorta of rat treated with cq-9 was effective in vasodilation response and significantly reduced the aggregation of rat platelets induced by collagen treatment. A cq-9, which is strongly associated with resistance to WBPH in rice, is also associated with positive effect of CLP surgery mice survival rate, vasodilation, and significantly reduced rat platelet aggregation induced by collagen treatment. Therefore, cq-9 presents research possibilities as a substance in a new paradigm that can act on both Plant-Insect in response to the present unpredictable future.

show abstract

Chemical Constituents of the Fungus Veronaea sp.

Cited by 6 publications

References 11 publications

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Bipolenins K–N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo

Contact Info

Product

Resources

About