Chemical Constituents of the Deep-Sea-Derived Penicillium solitum

Abstract

A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4–25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively).

α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2

“…Five other compounds were identified as 2‐(2' S ‐hydroxypropyl)‐5‐methyl‐7‐hydroxychromone ( 2 ), cyclonerodiol B ( 3 ), equisetin ( 4 ), 22 E ,24 R ‐ergosta‐7,22‐diene‐3β,5α,6β,9α‐tetraol ( 5 ), and N‐2’‐hydroxy‐3' E ‐octadecenoyl‐1‐O‐β‐ d ‐glucopyranosyl‐9‐methyl‐4 E ,8 E ‐sphingadiene ( 6 ) [21–25].…”

Marine natural products

“…215 Solitumergosterol A 585, is an unique 6/6/6/6/5 steroid obtained from P. solitum from deep-sea sediment, 216 as were polyketide 586 and alkaloids 587 and 588. 217 Penicillium steckii sourced from black band-diseased coral yielded new, 589 and 590, and known epithiodiketopiperazines with an a,b-polysulde bridge that underwent multiple nonenzymatic interconversions in solution. A further new analogue was present but not fully characterised.…”

“…215 Solitumergosterol A 585 , is an unique 6/6/6/6/5 steroid obtained from P. solitum from deep-sea sediment, 216 as were polyketide 586 and alkaloids 587 and 588 . 217…”

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

“…TW58-16 [62]. 15-O-methyl ML-236A (191) (Figure 4) was isolated from the deep-sea-sediment-derived P. solitum MCCC 3A00215 [69].…”