Chemical constituents of Polyalthia parviflora stem

Kaewamatawong, Rawiwun; Ruangrungsi, Nijsiri; Likhitwitayawuid, Kittisak

doi:10.1007/s11418-007-0138-7

Cited by 14 publications

(9 citation statements)

References 14 publications

(14 reference statements)

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“…8 Traditional healers in Asia use a water decoction of P. parvif lora to treat bodily discomfort. 9 Only one study has investigated the phytochemical constituents of P. parvif lora, reporting the isolation of p-coumarate, p-hydroxyphenylethyl ferulate, dehydrodiscretamine, and (−)-discretamine. 9 Due to the scarcity of reports on P. parvif lora, an extensive phytochemical and biological investigation on the secondary metabolite content of this species was initiated.…”

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confidence: 99%

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Bioactive 6S-Styryllactone Constituents of Polyalthia parviflora

Liou

Thăng

et al. 2014

J. Nat. Prod.

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Parvistones A-E (1-5), five new styryllactones possessing a rare α,β-lactone moiety and a 6S configuration, were isolated from a methanolic extract of Polyalthia parviflora leaves. The structures and the absolute configuration of the isolates were elucidated using NMR spectroscopy, specific rotation, circular dichroism, and X-ray single-crystal analysis. Compounds 8, 9, 11, and 12 were isolated for the first time. The results were supported by comparing the data measured to those of 6R-styryllactones. Moreover, a plausible biogenetic pathway of the isolated compounds was proposed. The structure-activity relationship of the compounds in an in vitro anti-inflammatory assay revealed the 6S-styryllactones to be more potent than the 6R derivatives. However, the effect was opposite regarding their cytotoxic activity. In addition, 6S-styrylpyrones isolated showed more potent anti-inflammatory and cytotoxic activity when compared to the 1S-phenylpyranopyrones obtained.

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“…Hydration and hydrogenation of 7 yield compound 10 and goniothalamin (8), respectively. The oxidation of the double bond between C-7 and C-8 of 8 results in the formation of goniothalamin oxide (9). Epoxide ring opening followed by halogenation (Cl − ) at the appropriate position with the aid of haloperoxidase provides 1.…”

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confidence: 99%

Bioactive 6S-Styryllactone Constituents of Polyalthia parviflora

Liou

Thăng

et al. 2014

J. Nat. Prod.

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“…Peaks 22 , 35 , 39 , 50 , 86 , 89 , 94 , and 99 were unambitiously identified by comparison with reference standards. Based on the relevant literature , peaks 11 , 17 , 20 , 30 , 40 , 42 , 43 , 44 , 46 , 51 , 54 , 82 , 139 , and 166 were tentatively assigned. Based on the online database retrieval (Chemspider), peak 26 was tentatively characterized.…”

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confidence: 99%

Profiling the constituents of Dachuanxiong decoction by liquid chromatography with high‐resolution tandem mass spectrometry using target and nontarget data mining

Liu

Wang

Chen

et al. 2019

J of Separation Science

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Comprehensive characterization of the large number of compounds existing in traditional Chinese medicines is still a great challenge. In this study, a strategy of precursor ion selected acquisition coupled with target and nontarget data mining was established to systematically characterize the chemical constituents of traditional Chinese medicines. This strategy consisted of four steps: (1) precursor ion selected acquisition was developed to trigger additional tandem mass spectrometry fragmentation reactions, especially for trace constituents; (2) in-house database of compounds was established and diagnostic characteristics were summarized; (3) compounds were identified by target and nontarget data mining; and (4) compound structures were elucidated based on accurate mass matching and comparison of fragment ions, and isomers were discriminated by the intensity of fragment ions, fragmentation pattern analysis, and calculated log P values. This strategy was successfully applied to comprehensively identify the constituents in Dachuanxiong decoction. Finally, a total of 218 compounds assigned to six categories were characterized, and 107 compounds were characterized by nontarget analysis for the first time. In addition, three new diagnostic characteristics of esters of citric acids were elucidated. This research enriched the material basis of Dachuanxiong decoction and provided a new strategy for identifying the chemical constituents of other traditional Chinese medicines. K E Y W O R D Schemical constituents, high-resolution tandem mass spectrometry, nontarget data mining, target data mining, traditional Chinese medicine Article Related Abbreviations: CGA, chlorogenic acid; DCXD, Dachuanxiong decoction; DPI, diagnostic product ion; ECA, ester of citric acid; MIs, molecular ions; NL, neutral loss; PIS, precursor ions selected; TCM, Traditional Chinese medicine.for combinatorial drug discovery [2]. Comprehensive identification of a large number of compounds present in TCMs is still a great challenge because TCMs contain a large number of constituents with diverse structures [3] and a wide range of concentrations [4]. High-resolution MS, particularly MS/MS or MS n , coupled with UHPLC has become the workhorse in the qualitative and quantitative analyses of TCMs because of its high selectivity, good sensitivity, and universality.Recent solutions to annotate the chemical constituents in TCMs can be mainly embodied in full data acquisition and 2202

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“…Two known cinnamic acid derivatives, p-hydroxyphenethyl-transferulate (4), first extracted from Heracleum lanatum (Nakata et al, 1982) and 2-hydroxyethyl-trans-ferulate (ariscucurbin A) (5), previously isolated from Aristolochia cucurbitifolia (Wu et al, 1999), and 3β,14β-dihydroxy-19-oxo-5β-bufa-20,22-dienolide 3-O-β-D-glucopyranoside (8), reported once previously from the related Madagascan Rhodocodon campanulatus (Schwikkard et al, 2017) were isolated. Compound 4 is a known free-radical scavenger (Hirano et al, 1997) which has also been shown to have an affinity toward serotonin (5-HT 7 ) receptors (Kaewamatawong et al, 2007).…”

Section: Isolation and Characterization Of Compounds From R Rotundus And R Cyathiformismentioning

confidence: 99%

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus,Rhodocodon rotundus and Rhodocodon cyathiformis

Mas‐Claret

Whitmore

Sishtla

et al. 2019

67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in Cooperat

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Chemical constituents of Polyalthia parviflora stem

Abstract: From the stem of Polyalthia parviflora, four compounds were isolated, including p-hydroxyphenylethyl p-coumarate (1), p-hydroxyphenylethyl ferulate (2), dehydrodiscretamine (3) and (-)-discretamine (4). Complete 1 H and 13 C NMR assignments were obtained for 1, 3 and 4 for the first time.

Cited by 14 publications

References 14 publications

Bioactive 6S-Styryllactone Constituents of Polyalthia parviflora

Bioactive 6S-Styryllactone Constituents of Polyalthia parviflora

Profiling the constituents of Dachuanxiong decoction by liquid chromatography with high‐resolution tandem mass spectrometry using target and nontarget data mining

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus,Rhodocodon rotundus and Rhodocodon cyathiformis

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