Chemical Constituents of Plants from the Genus <i>Euonymus</i>

Zhu, Jinhui; Qin, Jiang‐Jiang; Chang, Ruijie; Zeng, Qi; Cheng, Xiang‐Rong; Zhang, Fei; Jin, Hui‐Zi; Zhang, Guoqing

doi:10.1002/cbdv.201100170

Cited by 22 publications

(16 citation statements)

References 59 publications

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“…The majority of natural product inhibitors have been reported to down-regulate the expression of β-catenin and/or its coactivators, thereby inhibiting the transcription of its downstream target genes ( Table 1 ). Flavonoids are a class of ubiquitous polyphenolic natural products in medicinal plants and have recently been found to exert anticancer activities by targeting the β-catenin signaling ( Cheng et al., 2011b ; Wang et al., 2011 ; Zhu et al., 2012a ; Zhou et al., 2017 ). Baohuoside-I, a flavonoid from Cortex periplocae has been reported to down-regulate the expression of β-catenin and its downstream target gene Survivin and Cyclin D1 at both protein and mRNA levels ( Wang et al., 2011 ).…”

Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

et al. 2020

Front. Pharmacol.

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The mutations and deregulation of Wnt signaling pathway occur commonly in human cancer and cause the aberrant activation of b-catenin and b-catenin-dependent transcription, thus contributing to cancer development and progression. Therefore, bcatenin has been demonstrated as a promising target for cancer prevention and therapy. Many natural products have been characterized as inhibitors of the b-catenin signaling through down-regulating b-catenin expression, modulating its phosphorylation, promoting its ubiquitination and proteasomal degradation, inhibiting its nuclear translocation, or other molecular mechanisms. These natural product inhibitors have shown preventive and therapeutic efficacy in various cancer models in vitro and in vivo. In the present review, we comprehensively discuss the natural product b-catenin inhibitors, their in vitro and in vivo anticancer activities, and underlying molecular mechanisms. We also discuss the current b-catenin-targeting strategies and other potential strategies that may be examined for identifying new b-catenin inhibitors as cancer preventive and therapeutic drugs.

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Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

et al. 2020

Front. Pharmacol.

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“…Euonymus is a cosmopolitan genus of the family Celastraceae containing more than two hundred of species [ 1 ] mostly native in East Asia. Species Euonymus alatus L. is widely distributed and traditionally used as a medicinal plant in many Asian countries.…”

Section: Introductionmentioning

confidence: 99%

“…Species Euonymus alatus L. is widely distributed and traditionally used as a medicinal plant in many Asian countries. More than 230 chemical compounds have been identified and isolated from it, including sesquiterpenoids, diterpenoids, triterpenoids, flavonoids, phenylpropanoids, lignans, steroids, alkaloids, and other compounds [ 1 , 2 ]. Generally, Euonymus species have the potential for treatment of many injuries, inflammation, and oxidative stress as well as diseases including cancer, diabetes, and others [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Diacylglycerol Acetyltransferase Gene Isolated from Euonymus europaeus L. Altered Lipid Metabolism in Transgenic Plant towards the Production of Acetylated Triacylglycerols

Mihálik

Lančaričová

Mrkvová

et al. 2020

Life

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Euonymus species from the Celastraceae family are considered as a source of unusual genes modifying the oil content and fatty acid composition of vegetable oils. Due to the possession of genes encoding enzyme diacylglycerol acetyltransferase (DAcT), Euonymus plants can synthesize and accumulate acetylated triacyglycerols. The gene from Euonymus europaeus (EeDAcT) encoding the DAcT was identified, isolated, characterized, and modified for cloning and genetic transformation of plants. This gene has a unique nucleotide sequence and amino acid composition, different from orthologous genes from other Euonymus species. Nucleotide sequence of original EeDAcT gene was modified, cloned into transformation vector, and introduced into tobacco plants. Overexpression of EeDAcT gene was confirmed, and transgenic host plants produced and accumulated acetylated triacylglycerols (TAGs) in immature seeds. Individual transgenic plants showed difference in amounts of synthesized acetylTAGs and also in fatty acid composition of acetylTAGs.

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“…Our attention was drawn to the Spindle tree oil (Euonymus europaea L.), which, according to folk medicine, is effective in dermatomycosis and eczema [3][4][5][6][7]. However, data on the effectiveness of this oil in comparison with other dermatological agents and what kind of chemicals this action is stipulated, is not enough.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Chemical Composition and Efficiency of Seed Oil of Spindle Tree (Euonymus Europaea L.) on the Model of Non-Allergic Dermatitis

Vrubel

Nektegaev

Antonyuk

2018

EUREKA: Health Sciences

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Chemical Constituents of Plants from the Genus Euonymus

Cited by 22 publications

References 59 publications

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

Diacylglycerol Acetyltransferase Gene Isolated from Euonymus europaeus L. Altered Lipid Metabolism in Transgenic Plant towards the Production of Acetylated Triacylglycerols

Investigation of the Chemical Composition and Efficiency of Seed Oil of Spindle Tree (Euonymus Europaea L.) on the Model of Non-Allergic Dermatitis

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